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Efficacy of electrochemically activated water solution in gingivitis treatment

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Abstract

Mouthwash is one of the most commonly oral healthcare products for prevention and treatment of gum diseases. Dr. ECA is a disinfectant solution manufactured by a Vietnamese company and has been licensed for oral healthcare, but its effect on gingivitis is still unclear. To evaluate the effectiveness of this product in the treatment of gingivitis, we conducted a clinical study in 60 students diagnosed with gingivitis to compare the results of gingivitis treatment using Dr. ECA and a control mouthwash (a demonstrated anti-gingivitis product). The data showed that in the treated group, the rate of good Gingivitis Index (GI) before treatment was 46.67%, but after 2 and 4 weeks of using Dr. ECA that rate was increased to 96.67% and 100%, respectively. The percentage of patients with bleeding on probing was 63.33% but declined sharply after 2 weeks of treatment to 6.67%, and further reduced to 3.33% after 4 weeks of treatment. The treatment outcomes in were similar in the Dr. ECA treated group and control one with no statistically significant difference. Our results suggest that the electrolyte saline solution Dr. ECA is effective in treating gingivitis. Its effects are similar to other mouthwash products that had been approved and marketed.

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Funding

The EVD Group provided Dr. ECA solution and a part of the expenses for this research.

Author information

Author notes

  1. Truong Nhu Ngoc Vo, Dinh-Toi Chu, Duc Long Duong are Co-first authors.

Authors and Affiliations

  1. School of Odonto Stomatology, Hanoi Medical University, Hanoi, Vietnam

    Truong Nhu Ngoc Vo, Duc Long Duong, Minh Son Tong, Thi Thu Phuong Nguyen & Quynh Anh Le

  2. Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam

    Dinh-Toi Chu

  3. Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Gaustadalléen 21, 0349, Oslo, Norway

    Dinh-Toi Chu

  4. Department of Science and Technology Management, Hanoi Medical University, Hanoi, Vietnam

    Van Nhon Bui

  5. National Food Institute, Technical University of Denmark, 2800, Kongens Lyngby, Denmark

    Khanh-Hoang Nguyen

  6. AI Lab, Faculty of Information Technology, Ton Duc Thang University, Ho Chi Minh City, Vietnam

    Van-Huy Pham

  7. Institute for Research and Development, Duy Tan University, 03 Quang Trung, Danang, Vietnam

    Thien Chu-Dinh

Authors
  1. Truong Nhu Ngoc Vo
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  2. Dinh-Toi Chu
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  3. Duc Long Duong
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  4. Van Nhon Bui
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  5. Minh Son Tong
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  6. Thi Thu Phuong Nguyen
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  7. Quynh Anh Le
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  8. Khanh-Hoang Nguyen
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  9. Van-Huy Pham
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  10. Thien Chu-Dinh
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Contributions

TNNV and DTC designed experiments. VTNV, DLD, VNB and MST, TTPN and QAL designed, performed experiments, and collected data and informed consents. TNNV, DTC, KHN, VHP, and TCD analyzed and interpreted the results. VTNV, DLD, DTC, VHP, and TCD wrote the manuscript. DTC, KHN, VHP, and TCD edited the manuscript. All authors approved the final manuscript.

Corresponding authors

Correspondence to Van-Huy Pham or Thien Chu-Dinh.

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Conflict of interest

The authors declare no conflict of interest.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the Hanoi Medical University’s Ethics Council committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Hanoi Medical University’s Ethics Council committee (No. 121/HMU IRB).

Informed consent

Informed consent was obtained from the patients included in the study.

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Vo, T.N.N., Chu, DT., Duong, D.L. et al. Efficacy of electrochemically activated water solution in gingivitis treatment. J. Pharm. Investig. 49, 323–329 (2019). https://doi.org/10.1007/s40005-018-00419-7

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  • DOI: https://doi.org/10.1007/s40005-018-00419-7

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