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Gastro-News

, Volume 5, Issue 3, pp 46–53 | Cite as

Hepatische Eisenüberladung

Gute Prognose bei Therapie der Hämochromatose im Frühstadium

  • Claus Niederau
zertifizierte fortbildung
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Zusammenfassung

Veränderungen verschiedener Gene können zum histopathologischen und klinischen Bild der Hämochromatose führen. In Deutschland spielt vor allem der autosomal-rezessiv vererbte HFE-Typ 1 eine Rolle, bei dem die homozygote C282Y-Mutation zu einer erhöhten intestinalen Eisenresorption und somit im Verlauf von Jahrzehnten zu Eisenablagerung und Schädigung verschiedener Organe wie Leber, Pankreas, Herz und Gelenke führt.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Katholisches Klinikum Oberhausen, St. Josef-Hospital, Klinik für Innere Medizin, Akademisches Lehrkrankenhaus der Universität Duisburg-EssenOberhausenDeutschland

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