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Table 9 Detailed overview of individual reasons for prolongation of the hospital stay following availability of MEP results for the 63 patients of study center 1

From: The clinical impact of multiplex PCR panel diagnostics in paediatric meningitis/ encephalitis: a bicenter cohort study

ID Infusions and/or
symptomatic therapy 		Antibiotics/ acyclovir continued Further diagnostics (details) Monitoring Other specific therapeutic measures
1 x x Laboratory controls x None
2 x x Cerebral ct scan, eeg x None
3 x None ecg, toxicology workup x None
4 x x None x Nasal cannula suppl. oxygen
5 None x Ultrasound abdomen, eeg, neuropediatric assessment, ophtalmologic assessment x None
6 x x eeg x None
7 x x eeg, echocardiography x None
8 x None eeg, neuropediatric assessment x None
9 x x Lab diagnostics x None
10 x x None x (Physical therapy)
11 x x Extensive neuropediatric workup x Intravenous cortisone therapy
12 x x None x None
13 x None Multiple eegs, neuropediatric assessment x Antiepileptic therapy
14 x x None x (Physical therapy)
15 x x None x (Physical therapy)
16 None x Multiple eegs, neuropediatric assessment, ecg x None
17 x x None x None
18 x x None x (Physical therapy)
19 x None Laboratory diagnostics, eeg, emg x None
20 x x Ultrasound brains, regular laboratory controls x Nasal cannula suppl. oxygen
21 x x Ultrasound kidneys, urinalysis x None
22 x x Ultrasound abdomen, eeg; but MEP identifies relevant pathogen early! x None
23 x x eeg, neuropediatric assessment x None
24 x None Cerebral MRI, eeg, ecg, ultrasond thyroid gland, ENT-assessment x None
25 x x Laboratory controls x None
26 x None Multiple eegs, neuropediatric assessment, optalmologic assessment, ENT assessment, evaluation by psychologist x None
27 x None Eeg, evaluation by psychologist x None
28 x None eeg x None
29 x None Multiple eegs, cerebral MRI, ecg, opthalmologic assessment x Antiepileptic therapy
30 x x eeg x None
31 x x Extensive neuropediatric workup incl. cerebral MRI, neuropediatric assessment, multiple eegs, ecg x None
32 None None None None None
33 x None None x Cortisone therapy
34 x x None x None
35 x x eeg x None
38 x None eeg, ecg, echocardiography, cerebral MRI, psychologic evaluation x None
39 x None None x None
40 x x None x None
41 x x Ultrasound knee, eeg x None
42 x x ecg, echocardiography, multiple eegs x None
43 x x Extensive neuropediatric workup with eeg, elecrophysiology, ultrasound diagnostics x None
44 x x Ultrasound brains, abdomen, lab controls x None
45 x None Extensive neuropediatric workup with multiple eegs, ecg, MRI plexus brachialis, x-rays x Antiepileptic therapy, cortisone therapy
46 None x None x (Physical therapy)
47 x x None x None
48 x x None x None
49 x x multiple eegs x None
50 x x MRI spine, neuropediatric assessment, psychological evaluation, ENT evaluation x None
52 x x Ultrasound abdomen x None
53 x None MRI brains, multiple eegs, neuropediatric assessment, ultrasound hips, psychological evaluation x None
54 x x Laboratory controls x None
55 x x Lab diagnostics, ultrasound male genitalia x None
56 x None None x None
57 x None None x None
58 x x Ultrasound brains, kidneys, echocardiography, mcu x None
59 x None Multiple eegs, neuropediatric assessment, psychological evalulation x None
60 x None Neuropediatric evaluation x None
61 x x Ultrasound abdomen, further diagnostics at university hospital x None
62 x x Laboratory controls x Respiratory support with high-flow nasal cannula
63 x x Laboratory controls, ultrasound brains x None
64 x x Laboratory controls, diagnostic (and therapeutic) laparascopy x Laparascopic appendectomy
65 x x eeg, ecg, laboratory controls x None
66 x x Brain ultrasound, laboratory controls x None
  1. Please note that column 1 is not purely consecutively numbered but contains patient IDs as assigned originally (also used for references in the text)
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