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Fecal microbiota transplantation in a kidney transplant recipient with recurrent urinary tract infection

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Abstract

Purpose

We report on a kidney transplant recipient treated with fecal microbiota transplantation (FMT) for recurrent urinary tract infections.

Methods

FMT was administered via frozen capsulized microbiota. Before and after FMT, urinary, fecal and vaginal microbiota compositions were analyzed.

Results

The patient remained without symptoms after FMT.

Conclusions

Underlying mechanisms of action need to be addressed in depth by future research.

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Acknowledgements

We thank the patient for provision of clinical data and Anastasia Tsakmaklis and Fabiola Sack for excellent laboratory support.

Funding

This work was supported by the German Research Foundation (DFG) [BI 1899/1-1].

Author information

Authors and Affiliations

  1. Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany

    Lena M. Biehl, Rebeca Cruz Aguilar, Fedja Farowski & Maria J. G. T. Vehreschild

  2. German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany

    Lena M. Biehl, Rebeca Cruz Aguilar & Maria J. G. T. Vehreschild

  3. Practice for Nephrology and Hypertension, Dialysis, Mayen, Germany

    Werner Hahn

  4. Wisplinghoff Laboratories, Cologne, Germany

    Angela Nowag & Hilmar Wisplinghoff

  5. Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany

    Angela Nowag & Hilmar Wisplinghoff

  6. Institute for Virology and Medical Microbiology, Witten/Herdecke University, Witten, Germany

    Hilmar Wisplinghoff

Authors
  1. Lena M. Biehl
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  2. Rebeca Cruz Aguilar
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  3. Fedja Farowski
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  4. Werner Hahn
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  5. Angela Nowag
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  6. Hilmar Wisplinghoff
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  7. Maria J. G. T. Vehreschild
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Corresponding author

Correspondence to Maria J. G. T. Vehreschild.

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Conflict of interest

LMB has received lecture honoraria from Astellas and Merck/MSD, and travel grants from 3M and Gilead. MJGTV reports grants and personal fees from Astellas Pharma, Merck/MSD, Gilead Sciences, Berlin Chemie, Falk Foundation, Organobalance, Pfizer, and grants from Astellas Pharma, Merck/MSD, Seres Therapeutics, DaVolterra. All other authors: none to declare.

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Biehl, L.M., Cruz Aguilar, R., Farowski, F. et al. Fecal microbiota transplantation in a kidney transplant recipient with recurrent urinary tract infection. Infection 46, 871–874 (2018). https://doi.org/10.1007/s15010-018-1190-9

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  • DOI: https://doi.org/10.1007/s15010-018-1190-9

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