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Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin

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Abstract

Introduction

Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking.

Case report

We report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. The treatment was capable of rapidly inducing both HCV and HEV viral suppression.

Conclusion

In conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.

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Authors and Affiliations

  1. Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy

    Elisa Biliotti, Cristiana Franchi, Martina Spaziante, Lorenzo Volpicelli, Donatella Palazzo, Maurizio De Angelis, Rozenn Esvan & Gloria Taliani

  2. Laboratory of Virology, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy

    Anna Rosa Garbuglia

Authors
  1. Elisa Biliotti
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  2. Cristiana Franchi
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  3. Martina Spaziante
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  4. Anna Rosa Garbuglia
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  5. Lorenzo Volpicelli
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  6. Donatella Palazzo
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  7. Maurizio De Angelis
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  8. Rozenn Esvan
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  9. Gloria Taliani
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Corresponding author

Correspondence to Elisa Biliotti.

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All authors have nothing to disclose regarding funding or conflict of interest with respect to this manuscript.

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Biliotti, E., Franchi, C., Spaziante, M. et al. Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin. Infection 46, 725–727 (2018). https://doi.org/10.1007/s15010-018-1168-7

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  • DOI: https://doi.org/10.1007/s15010-018-1168-7

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