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Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton

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Abstract

Purpose

The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections.

Methods

An observational study (1993–2014) which includes two cohorts: (1) patients with IE (n = 607) and (2) patients with bacteremic OAIs (n = 458; septic arthritis of peripheral and axial skeleton, and vertebral and peripheral osteomyelitis). These two cohorts were prospectively collected, and we retrospectively reviewed the clinical and microbiological variables.

Results

There were 70 cases of IE with concomitant OAIs, representing 11.5% of IE cases and 15% of bacteremic OAI cases. Among cases with IE, the associated OAIs mainly involved the axial skeleton (n = 54, 77%): 43 were vertebral osteomyelitis (61%), mainly caused by “less virulent” bacteria (viridans and bovis streptococci, enterococci, and coagulase-negative staphylococci), and 15 were septic arthritis of the axial skeleton (21%), which were mainly caused by Staphylococcus aureus. OAIs with involvement of the axial skeleton were associated with IE (adjusted OR = 2.2; 95% CI 1.1–4.3) independently of age, sex, and microorganisms.

Conclusions

Among patients with IE, the associated OAIs mainly involve the axial skeleton. Transesophageal echocardiography should be carefully considered in patients presenting with these bacteremic OAIs.

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Acknowledgements

We thank Michael Maudsley for helping with the English in this manuscript.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Infectious Diseases Department, IDIBELL-Hospital Universitari de Bellvitge, University of Barcelona, Feixa Llarga s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain

    Oscar Murillo, Imma Grau, Joan Gomez-Junyent, Celina Cabrera, Alba Ribera, Carmen Peña, Javier Ariza & Roman Pallares

  2. Microbiology Department, IDIBELL-Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain

    Fe Tubau

  3. Spain Ciber de Enfermedades Respiratorias ISCIII, Madrid, Spain

    Fe Tubau

Authors
  1. Oscar Murillo
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  2. Imma Grau
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  3. Joan Gomez-Junyent
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  4. Celina Cabrera
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  5. Alba Ribera
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  6. Fe Tubau
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  7. Carmen Peña
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  8. Javier Ariza
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  9. Roman Pallares
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Corresponding author

Correspondence to Oscar Murillo.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The institutional review board approved this study and publication of the results. The need for informed consent was waived as the study analysed data retrospectively and the data were anonymized.

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Murillo, O., Grau, I., Gomez-Junyent, J. et al. Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. Infection 46, 245–251 (2018). https://doi.org/10.1007/s15010-018-1121-9

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  • DOI: https://doi.org/10.1007/s15010-018-1121-9

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