Most of the species from the genus Kocuria are environmental or commensals of mammalian skin and oral bacteria, and had rarely been associated with human infection. However, recent reports showed an increase of the clinical role of these bacteria in human infectious diseases. Most of the cases occurred in hospitals and were device related. They included bacteremia, peritonitis, abscess, endocarditis and ocular infection. We here describe the main characteristics and the draft genome of Kocuria massiliensis sp. nov., strain P3598T (CSURP3598), a new Kocuria species that caused foot osteomyelitis in a 78-year-old woman. The improvement of diagnostic tools for the identification of bacteria in microbiological laboratories, including MALDI-TOF MS and 16S rRNA sequencing, largely contributed to the emergence and to the expansion of the clinical spectrum of infections caused by Kocuria spp. To the best of our knowledge, we report here the first case of osteomyelitis with a bacterial species from the genus Kocuria.
Kocuria massiliensisOsteitis MALDI-TOF MS Genome 16S rRNA gene
This is a preview of subscription content, log in to check access
Compliance with ethical standards
Conflict of interest
None to declare.
This work was funded by Méditerranée-Infection Foundation.
Seng P, Drancourt M, Gouriet F, La SB, Fournier PE, Rolain JM, et al. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis. 2009;49:543–51.CrossRefPubMedGoogle Scholar
Drancourt M, Bollet C, Carlioz A, Martelin R, Gayral JP, Raoult D. 16S ribosomal DNA sequence analysis of a large collection of environmental and clinical unidentifiable bacterial isolates. J Clin Microbiol. 2000;38:3623–30.PubMedPubMedCentralGoogle Scholar
Stackebrandt E, Ebers J. Taxonomic parameters revisited: tarnished gold standards. Microbiol today. 2006;33:152.Google Scholar
Kim M, Oh HS, Park SC, Chun J. Towards a taxonomic coherence between average nucleotide identity and 16S rRNA gene sequence similarity for species demarcation of prokaryotes. Int J Syst Evol Microbiol. 2014;64:346–51.CrossRefPubMedGoogle Scholar
Domont F, le Fleche-Mateos A, Brémond-Gignac D, Hamdad F. Kocuria dacryocystitis infection, caused by Kocuria ocularis sp. nov. J Med Microbiol Case Rep. 2014;. doi:10.1099/jmmcr.0.002022.Google Scholar
Stackebrandt E, Koch C, Gvozdiak O, Schumann P. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend. Int J Syst Bacteriol. 1995;45:682–92.CrossRefPubMedGoogle Scholar
Purty S, Saranathan R, Prashanth K, Narayanan K, Asir J, Sheela DC, et al. The expanding spectrum of human infections caused by Kocuria species: a case report and literature review. Emerg Microbes Infect. 2013;2:e71.CrossRefPubMedPubMedCentralGoogle Scholar
Savini V, Catavitello C, Masciarelli G, Astolfi D, Balbinot A, Bianco A, et al. Drug sensitivity and clinical impact of members of the genus Kocuria. J Med Microbiol. 2010;59:1395–402.CrossRefPubMedGoogle Scholar
Sohn KM, Baek JY, Kim SH, Cheon S, Kim YS. Catheter-related bacteremia caused by Kocuria salsiccia: the first case. J Infect Chemother. 2015;21:305–7.CrossRefPubMedGoogle Scholar
Kandi V, Palange P, Vaish R, Bhatti AB, Kale V, Kandi MR, et al. Emerging Bacterial infection: identification and clinical significance of Kocuria sp. Cureus. 2016;8:e731.PubMedPubMedCentralGoogle Scholar
Brandle G, L’Huillier AG, Wagner N, Gervaix A, Wildhaber BE, Lacroix L. First report of Kocuria marina spontaneous peritonitis in a child. BMC Infect Dis. 2014;14:719.CrossRefPubMedPubMedCentralGoogle Scholar
Seng P, Abat C, Rolain JM, Colson P, Lagier JC, Gouriet F, et al. Identification of rare pathogenic bacteria in a clinical microbiology laboratory: impact of matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2013;51:2182–94.CrossRefPubMedPubMedCentralGoogle Scholar
Abdallah RA, Beye M, Diop A, Bakour S, Raoult D, Fournier PE. The impact of culturomics on taxonomy in clinical microbiology. Antonie Van Leeuwenhoek. 2017;110:1327–37.CrossRefPubMedGoogle Scholar