, Volume 45, Issue 2, pp 227–231 | Cite as

A retrospective study of viral central nervous system infections: relationship amongst aetiology, clinical course and outcome

  • Guido Calleri
  • Valentina Libanore
  • Silvia Corcione
  • Francesco G. De Rosa
  • Pietro Caramello
Brief Report



To describe the clinical pattern of viral central nervous system (CNS) infections and compare meningitis and encephalitis.


This is a retrospective study reporting the clinical characteristics and outcome of 138 cases of viral meningitis and meningoencephalitis in a real life experience at a referral centre in Turin, Northern Italy.


Enteroviruses were predominant in younger patients who were mainly presenting with signs of meningitis, had shorter hospital admission and absence of complications, whereas herpesviruses had more often signs of encephalitis, were more frequent in elderly patients, had longer hospital admission and frequent complications and sequelae.


Two main clinical entities with different epidemiology, clinical aspects and prognosis may be identified within the group of viral CNS inefctions.


Central nervous system Viral diseases Encephalitis Meningitis Retrospective Case series 



This work was supported by the “Fondazione Carlo Denegri ONLUS”, Torino, Italy.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Travel Medicine UnitAmedeo di Savoia HospitalTurinItaly
  2. 2.Infectious Diseases UnitCardinal Massaia HospitalAstiItaly
  3. 3.Department of Medical Sciences, Amedeo di Savoia HospitalUniversity of TorinoTurinItaly
  4. 4.Infectious and Tropical Diseases UnitAmedeo di Savoia HospitalTurinItaly

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