Trimethoprim–sulfamethoxazole therapy for patients with carbapenemase-producing Klebsiella pneumoniae infections: retrospective single-center case series
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The objective of the study was to evaluate the efficacy and tolerability of trimethoprim–sulfamethoxazole (also known as co-trimoxazole, TMPS) to treat Klebsiella pneumoniae (Kp)-K. pneumoniae carbapenemase (KPC) infections.
Clinical data of patients with a TMPS-susceptible Kp-KPC infection were collected as a case series.
We report clinical outcomes and tolerability for 14 patients infected by Kp-KPC strains susceptible to TMPS, including three bloodstream infections. In ten cases (71.4%), TMPS was administered as monotherapy. In all but one case, Kp-KPC infection was cured. In the remaining patient, therapy was discontinued because of an adverse event.
The use of TMPS to treat TMPS-susceptible Kp-KPC infections seems promising.
KeywordsKPC Carbapenemase Trimethoprim–sulfamethoxazole Co-trimoxazole Multidrug-resistant infections
We are grateful to Leonida Passeri for his technical assistance in data management.
Compliance with ethical standards
Conflict of interest
No funding has been received for this study. The present manuscript was revised by San Francisco Edit, which was supported by internal funding. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
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