, Volume 45, Issue 2, pp 237–240 | Cite as

Vibrio cholerae non-O1, non-O139 bacteraemia associated with pneumonia, Italy 2016

  • Serena Marinello
  • Giulia Marini
  • Giancarlo Parisi
  • Lorena Gottardello
  • Lucia Rossi
  • Valeria Besutti
  • Anna Maria Cattelan
Case Report


This paper describes an elderly male patient, living in the Veneto Region, Italy, who developed Vibrio cholerae bacteraemia and pneumonia. Some days previously, while on holiday in the Lagoon of Venice, he had been collecting clams in seawater, during which he suffered small abrasions of the skin. On admission to hospital, he was confused, had fever and a cough, but neither diarrhoea nor signs of gastroenteritis were found. Both blood and stool cultures grew V. cholerae of non-O1 non-O-139 type, and the patient recovered after prompt administration of intravenous ceftriaxone for 2 weeks. This clinical case emphasises the role of global warming and climate changes in causing increasing numbers of water-borne infections.


Vibrio infection Food borne infections Pneumonia 



We are grateful to Dr. Ida Luzzi for confirmation of the Vibrio cholerae serogroup at the Istituto Superiore della Sanità, Rome, Italy, and to Dr. Andrea Sattin for clinical care of the patient.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    Hlady WG, Klontz KC. The epidemiology of Vibrio infections in Florida, 1981–1993. J Infect Dis. 1996;173:1176–83.CrossRefPubMedGoogle Scholar
  2. 2.
    Crowe SJ, Newton AE, Gould LH, et al. Vibriosis, not cholerae: toxigenic Vibrio cholerae non-O1, non-O139 infections in the United States, 1984–2014. Epidemiol Infect. 2016;11:1–7.Google Scholar
  3. 3.
    Morris JG Jr. Non-O group 1 Vibrio cholerae: a look at the epidemiology of an occasional pathogen. Epidemiol Rev. 1990;12:179–91.CrossRefPubMedGoogle Scholar
  4. 4.
    Hao Y, Wang Y, Bi Z, et al. A case of non-O1/non-O139 Vibrio cholerae septicemia and meningitis in a neonate. Int J Infect Dis. 2015;35:117–9.CrossRefPubMedGoogle Scholar
  5. 5.
    Engel MF, Muijsken MA, Mooi-Kokenberg E, Kuijper EJ, van Westerloo DJ. Vibrio cholerae non-O1 bacteraemia: description of three cases in the Netherlands and a literature review. Euro Surveill. 2016;21:30197. doi: 10.2807/1560-7917.ES.2016.21.15.30197.CrossRefGoogle Scholar
  6. 6.
    Shannon JD, Kimbrough RC. Pulmonary cholera due to infection with a non-O1 Vibrio cholerae strain. J Clin Microbiol. 2006;44:3459–60.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Ko WC, Chuang YC, Huang GC, et al. Infections due to non-O1 Vibrio cholerae in southern Taiwan: predominance in cirrhotic patients. Clin Infect Dis. 1998;27:774–80.CrossRefPubMedGoogle Scholar
  8. 8.
    Halabi M, Haditsch M, Renner F, et al. Vibrio cholerae non-O1 septicaemia in a patient with liver cirrhosis and Billroth-II-gastrectomy. J Infect. 1997;34:83–4.CrossRefPubMedGoogle Scholar
  9. 9.
    Tamura S, Taniguchi F, Nakamoto C, et al. Fatal diarrheal disease caused by Vibrio cholerae O67 in a patient with myelodysplastic syndrome. Intern Med. 2013;52:1635–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Marek A, Inkster T, Anderson E, et al. Non-toxigenic Vibrio cholerae bacteraemia: case report and review of the literature. J Med Microbiol. 2013;62:1357–9.CrossRefPubMedGoogle Scholar
  11. 11.
    Trubiano JA, Lee JY, Valcanis M, et al. Non-O1, non-O139 Vibrio cholerae bacteraemia in an Australian population. Intern Med J. 2014;44:508–11.CrossRefPubMedGoogle Scholar
  12. 12.
    Hirk S, Huhulescu S, Allerberger F, et al. Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites. Wien Klin Wochenschr. 2016;128:141–5.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Ottaviani D, Leoni F, Rocchegiani E, et al. Prevalence and virulence properties of non-O1 non-O139 Vibrio cholerae strains from seafood and clinical samples collected in Italy. Int J Food Microbiol. 2009;132:47–53.CrossRefPubMedGoogle Scholar
  14. 14.
    Piergentili P, Castellani-Pastoris M, Fellini RD, et al. Transmission of non O group 1 Vibrio cholerae by raw oyster consumption. Int J Epidemiol. 1984;13:340–3.CrossRefPubMedGoogle Scholar
  15. 15.
    Hoshino K, Yamasaki S, Mukhopadhyay AK, et al. Development and evaluation of a multiplex PCR assay for rapid detection of toxigenic Vibrio cholerae O1 and O139. FEMS Immunol Med Microbiol. 1998;20:201–7.CrossRefPubMedGoogle Scholar
  16. 16.
    Chow KH, Nq TK, Yuen KY, et al. Detection of RTX toxin gene in Vibrio cholerae by PCR. J Clin Microbiol. 2001;39:2594–7.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Rivera IN, Chun J, Huq A, et al. Genotypes associated with virulence in environmental isolates of Vibrio cholerae. Appl Environ Microbiol. 2001;67:2421–9CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Jonson JA, Panigrahi P, Morris JG. Non-O1 Vibrio cholera NRT36S produces a polysaccharide capsule that determines colony morphology, serum resistance, and virulence in mice. Infect Immun. 1992;60:864.Google Scholar
  19. 19.
    Petsaris O, Nousbaum JB, Quilici ML, et al. Non-O1, Non-O1, non-O139 Vibrio cholerae bacteraemia in cirrhotic patient. J Med Microbiol. 2010;59:1260–2.CrossRefPubMedGoogle Scholar
  20. 20.
    Rahman MS, Martino ME, Cardazzo B, et al. Vibrio trends in the ecology of the Venice lagoon. Appl Environ Microbiol. 2014;80:2372–80.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Infectious DiseasesAzienda Ospedaliera and University of PadovaPaduaItaly
  2. 2.Department of Internal MedicineHospital of Piove di SaccoPaduaItaly
  3. 3.Department of Hygiene and Public HealthAzienda Ospedaliera and University of PadovaPaduaItaly
  4. 4.Department of MicrobiologyAzienda Ospedaliera and University of PadovaPaduaItaly

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