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Severe Reactivation of Hepatitis B Virus Infection in a Patient with Hairy Cell Leukemia: Should Lamivudine Prophylaxis be Recommended to HBsAg-Negative, Anti-HBc-Positive Patients?

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Abstract

The reverse seroconversion to hepatitis B virus infection has been sporadically described in onco-haematological patients receiving cytotoxic therapy or allogeneic bone marrow transplantation and can be associated with the development of acute icteric hepatitis. We present a male HBsAg-negative, anti-HBc-positive patient with Hairy Cell Leukemia who developed acute B hepatitis more than 1 year after the last course of 2-CdA and 6 months after splenectomy, while the patient was receiving therapy with αIFNr. The acute B hepatitis promptly responded to lamivudine therapy followed by viral clearance.

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Authors and Affiliations

  1. Dept. of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy

    R. Orlando

  2. Dept. of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, Naples, Italy

    R. Orlando, G. Tosone, D. Tiseo & M. Piazza

  3. Dept. of Biology and Cellular Molecular Pathology, University of Naples Federico II, Naples, Italy

    G. Portella

  4. Dept. of Medical Biochemistry and Biotechnology—Haematology Division, University of Naples Federico II, Naples, Italy

    R. Ciancia, V. Martinelli, B. Montante & B. Rotoli

Authors
  1. R. Orlando
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  2. G. Tosone
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  3. D. Tiseo
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  4. M. Piazza
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  5. G. Portella
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  6. R. Ciancia
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  7. V. Martinelli
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  8. B. Montante
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  9. B. Rotoli
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Corresponding author

Correspondence to R. Orlando.

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Orlando, R., Tosone, G., Tiseo, D. et al. Severe Reactivation of Hepatitis B Virus Infection in a Patient with Hairy Cell Leukemia: Should Lamivudine Prophylaxis be Recommended to HBsAg-Negative, Anti-HBc-Positive Patients?. Infection 34, 282–284 (2006). https://doi.org/10.1007/s15010-006-4150-8

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  • DOI: https://doi.org/10.1007/s15010-006-4150-8

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