Skip to main content
Log in

Nichtinfektiöse Komplikationen

Lungenbeteiligung bei hämatologischen Systemerkrankungen

  • zertifizierte fortbildung
  • Published:
InFo Hämatologie + Onkologie Aims and scope

Zusammenfassung

Bei Patienten mit hämatologischen Neoplasien kommt es infolge von Erkrankung und Therapie häufiger zu infektiösen Veränderungen der Lunge. Darüber hinaus kann aber auch die maligne Erkrankung selbst primär oder sekundär die Lunge beeinträchtigen — zum Beispiel als Lungeninfiltrat oder im Zusammenhang mit einer Leukostase. Lesen Sie im Folgenden, welche dieser nichtinfektiösen Veränderungen häufiger auftreten und wie diese zu behandeln sind.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

1
2
3
4
5
6

Literatur

  1. Ahmed S et al. Pulmonary complications in chronic lymphocytic leukemia. Cancer. 2003;98(9):1912–7

    PubMed  Google Scholar 

  2. Balikian JP, Herman PG. Non-Hodgkin lymphoma of the lungs. Radiology. 1979;132(3):569–76

    CAS  PubMed  Google Scholar 

  3. Bashoura L et al. Pulmonary manifestations of Lymphoma and leukemia. Clin Chest Med. 2017;38(2):187–200

    PubMed  Google Scholar 

  4. Berkman N et al. Pulmonary involvement in lymphoma. Leuk Lymphoma. 1996;20(3-4):229–37

    CAS  PubMed  Google Scholar 

  5. Blom JW et al. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA. 2005;293(6):715–22

    CAS  PubMed  Google Scholar 

  6. Bodey GP et al. Pulmonary complications of acute leukemia. Cancer. 1966;19(6):781–93

    CAS  PubMed  Google Scholar 

  7. Bragg DG et al. Lymphoproliferative disorders of the lung: histopathology, clinical manifestations, and imaging features. AJR Am J Roentgenol. 1994;163(2):273–81

    CAS  PubMed  Google Scholar 

  8. Brixey AG, Light RW. Pleural effusions due to dasatinib. Curr Opin Pulm Med. 2010;16(4):351–6

    PubMed  Google Scholar 

  9. Byrd JC et al. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol. 1995;13(7):1800–16

    CAS  PubMed  Google Scholar 

  10. Cazzadori A et al. Transbronchial biopsy in the diagnosis of pulmonary infiltrates in immunocompromised patients. Chest. 1995;107(1):101–6

    CAS  PubMed  Google Scholar 

  11. Chaulagain CP et al. Secondary pulmonary alveolar proteinosis in hematologic malignancies. Hematol Oncol Stem Cell Ther. 2014;7(4):127–35

    PubMed  Google Scholar 

  12. Cheng S. Superior vena cava syndrome: a contemporary review of a historic disease. Cardiol Rev. 2009;17(1):16–23

    PubMed  Google Scholar 

  13. Chung JH et al. Secondary pulmonary alveolar proteinosis: a confusing and potentially serious complication of hematologic malignancy. J Thorac Imaging. 2009;24(2):115–8

    PubMed  PubMed Central  Google Scholar 

  14. Ciurea-Lochel A et al. Lung infiltrations in Hodgkin lymphoma. Praxis (Bern 1994). 2001;90(31-32):1307–11

    CAS  Google Scholar 

  15. Cordier JF et al. Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients. Chest. 1993;103(1):201–8

    CAS  PubMed  Google Scholar 

  16. Cordonnier C et al. Secondary alveolar proteinosis is a reversible cause of respiratory failure in leukemic patients. Am J Respir Crit Care Med. 1994;149(3 Pt 1):788–94

    CAS  PubMed  Google Scholar 

  17. Duwe BV et al. Tumors of the mediastinum. Chest. 2005;128(4):2893–909

    PubMed  Google Scholar 

  18. Faiz SA et al. Pleural effusions in patients with acute leukemia and myelodysplastic syndrome. Leuk Lymphoma. 2013;54(2):329–35

    PubMed  Google Scholar 

  19. Falanga A, Marchetti M. Anticancer treatment and thrombosis. Thromb Res. 2012;129(3):353–9

    CAS  PubMed  Google Scholar 

  20. Falanga A, Marchetti M. Thrombotic disease in the myeloproliferative neoplasms. Hematology Am Soc Hematol Educ Program. 2012;2012:571–81

    PubMed  Google Scholar 

  21. Falanga A et al. Venous thromboembolism in the hematologic malignancies. Curr Opin Oncol. 2012;24(6):702–10

    CAS  PubMed  Google Scholar 

  22. Fiche M et al. Primary pulmonary non-Hodgkin’s lymphomas. Histopathology. 1995;26(6):529–37

    CAS  PubMed  Google Scholar 

  23. Green RJ et al. Pulmonary capillaritis and alveolar hemorrhage. Update on diagnosis and management. Chest. 1996;110(5):1305–16

    CAS  PubMed  Google Scholar 

  24. Griese M et al. Surfactant in children with malignancies, immunosuppression, fever and pulmonary infiltrates. Eur Respir J. 2002;20(5):1284–91

    CAS  PubMed  Google Scholar 

  25. Grosu HB et al. Endobronchial ultrasound-guided Transbronchial needle aspiration for the diagnosis and subtyping of lymphoma. Ann Am Thorac Soc. 2015;12(9):1336–44

    PubMed  Google Scholar 

  26. Guilpain P et al. Pulmonary hypertension associated with myeloproliferative disorders: a retrospective study of ten cases. Respiration. 2008;76(3):295–302

    CAS  PubMed  Google Scholar 

  27. Hess CE et al. Pseudohypoxemia secondary to leukemia and thrombocytosis. N Engl J Med. 1979;301(7):361–3

    CAS  PubMed  Google Scholar 

  28. Joseph G et al. Primary pulmonary plasmacytoma. Cancer. 1993;71(3):721–4

    CAS  PubMed  Google Scholar 

  29. Kintzer JS Jr. et al. Thoracic and pulmonary abnormalities in multiple myeloma. A review of 958 cases. Arch Intern Med. 1978;138(5):727–30

    PubMed  Google Scholar 

  30. Kligerman SJ et al. Primary extranodal lymphoma of the thorax. Radiol Clin North Am. 2016;54(4):673–87

    PubMed  Google Scholar 

  31. Ko HM et al. Diagnosis and subclassification of lymphomas and non-neoplastic lesions involving mediastinal lymph nodes using endobronchial ultrasound-guided transbronchial needle aspiration. Diagn Cytopathol. 2013;41(12):1023–30

    PubMed  Google Scholar 

  32. Koch CA et al. Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 2003;78(10):1223–33

    PubMed  Google Scholar 

  33. Le Coutre PD et al. Low incidence of peripheral arterial disease in patients receiving dasatinib in clinical trials. Leukemia. 2016;30(7):1593–6

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Macdonald JB. Lung involvement in Hodgkin’s disease. Thorax. 1977;32(6):664–7

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Miller DL, Allen MS. Rare pulmonary neoplasms. Mayo Clin Proc. 1993;68(5):492–8

    CAS  PubMed  Google Scholar 

  36. Moonim MT et al. Diagnosis and subtyping of de novo and relapsed mediastinal lymphomas by endobronchial ultrasound needle aspiration. Am J Respir Crit Care Med. 2013;188(10):1216–23

    PubMed  PubMed Central  Google Scholar 

  37. Nanjappa S et al. Diffuse alveolar hemorrhage in acute myeloid leukemia. Cancer Control. 2016;23(3):272–7

    PubMed  Google Scholar 

  38. Pastore F et al. The role of therapeutic leukapheresis in hyperleukocytotic AML. PLoS One. 2014;9(4):e95062

    PubMed  PubMed Central  Google Scholar 

  39. Paydas S et al. Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma. 2006;47(12):2527–41

    PubMed  Google Scholar 

  40. Poletti V, Costabel U, Semenzato G (2005) Pulmonary complications in patients with hematological disorders: pathobiological bases and practical approach. Semin Respir Crit Care Med. 2005;26(5):439–44

    PubMed  Google Scholar 

  41. Poletti V et al. Transbronchial lung biopsy in pulmonary sarcoidosis. Is it an evaluable method in detection of disease activity?. Chest. 1986;89(3):361–5

    CAS  PubMed  Google Scholar 

  42. Poletti V et al. The lung as a target organ in patients with hematologic disorders. Haematologica. 2000;85(8):855–64

    CAS  PubMed  Google Scholar 

  43. Porcel JM et al. Etiology of pleural effusions: analysis of more than 3,000 consecutive thoracenteses. Arch Bronconeumol. 2014;50(5):161–5

    PubMed  Google Scholar 

  44. Portell CA, Sweetenham JW. Adult lymphoblastic lymphoma. Cancer J. 2012;18(5):432–8

    CAS  PubMed  Google Scholar 

  45. Radin AI. Primary pulmonary Hodgkin’s disease. Cancer. 1990;65(3):550–63

    CAS  PubMed  Google Scholar 

  46. Roberts AS et al. Extramedullary haematopoiesis: radiological imaging features. Clin Radiol. 2016;71(9):807–14

    CAS  PubMed  Google Scholar 

  47. Ross JS, Ellman L. Leukemic infiltration of the lungs in the chemotherapeutic era. Am J Clin Pathol. 1974;61(2):235–41

    CAS  PubMed  Google Scholar 

  48. Shaffer K et al. Primary mediastinal large-B-cell lymphoma: radiologic findings at presentation. AJR Am J Roentgenol. 1996;167(2):425–30

    CAS  PubMed  Google Scholar 

  49. Shah NP et al. Clinical features of pulmonary arterial hypertension in patients receiving dasatinib. Am J Hematol. 2015;90(11):1060–4

    CAS  PubMed  Google Scholar 

  50. Stemmler J et al. Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure. Leuk Lymphoma. 2002;43(7):1427–30

    CAS  PubMed  Google Scholar 

  51. Takasugi JE et al. Intrathoracic granulocytic sarcomas. J Thorac Imaging. 1996;11(3):223–30.

    CAS  PubMed  Google Scholar 

  52. Von Eiff M et al. Pulmonary aspergillosis: early diagnosis improves survival. Respiration. 1995;62(6):341–7

    CAS  PubMed  Google Scholar 

  53. Von Eiff M et al. Differential cell count and lymphocyte subsets in bronchoalveolar lavage during pneumonia with and without peripheral neutropenia. Lung. 1995;173(1):25–33

    CAS  PubMed  Google Scholar 

  54. Von Eiff M et al. Pulmonary fungal infections in patients with hematological malignancies—diagnostic approaches. Ann Hematol. 1995;70(3):135–41

    CAS  PubMed  Google Scholar 

  55. Von Eiff M et al. Pulmonary infiltrates in patients with haematologic malignancies: clinical usefulness of non-invasive bronchoscopic procedures. Eur J Haematol. 1995;54(3):157–62

    CAS  PubMed  Google Scholar 

  56. Vu K et al. A retrospective study of venous thromboembolism in acute leukemia patients treated at the University of Texas MD Anderson cancer center. Cancer Med. 2015;4(1):27–35

    PubMed  Google Scholar 

  57. Wang HQ, Li J. Clinicopathological features of myeloid sarcoma: Report of 39 cases and literature review. Pathol Res Pract. 2016;212(9):817–24

    PubMed  Google Scholar 

  58. Wilson LD et al. Clinical practice. Superior vena cava syndrome with malignant causes. N Engl J Med. 2007;356(18):1862–9

    CAS  PubMed  Google Scholar 

  59. Yousem SA et al. Primary pulmonary Hodgkin’s disease. A clinicopathologic study of 15 cases. Cancer. 1986;57(6):1217–24

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hans-Joachim Stemmler.

Additional information

Die Autoren Stephanie Susanne Stecher und Stephanie Lippl haben gleichermaßen zum Manuskript beigetragen. Der Beitrag ist eine aktualisierte und ergänzte Übernahme des Beitrages Stecher SS et al. Internist. 2018;59(9):886-97.

Interessenkonflikt

Die Autoren erklären, dass sie sich bei der Erstellung des Beitrags von keinen wirtschaftlichen Interessen leiten ließen. Die Autoren legen folgende potenzielle Interessenkonflikte offen: keine. Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheitsbildes geeignet sind.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stecher, S.S., Lippl, S., Stemmler, HJ. et al. Lungenbeteiligung bei hämatologischen Systemerkrankungen. Info Onkol. 22, 33–43 (2019). https://doi.org/10.1007/s15004-019-6362-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15004-019-6362-y

Navigation