Hereditary leukodystrophy with axonal spheroids (HDLS) presenting subacutely: a CNS-vasculitis mimic

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2

References

  1. 1.

    Sundal C, Lash J, Aasly J, Øygarden S, Roeber S, Kretzschman H, Garbern JY, Tselis A, Rademakers R, Dickson DW, Broderick D, Wszolek ZK (2012) Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): a misdiagnosed disease entity. J Neurol Sci 314(1–2):130–137. https://doi.org/10.1016/j.jns.2011.10.006

    Article  PubMed  Google Scholar 

  2. 2.

    Bender B, Klose U, Lindig T, Biskup S, Nägele T, Schöls L, Karle KN (2014) Imaging features in conventional MRI, spectroscopy and diffusion weighted images of hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS). J Neurol 261(12):2351–2359. https://doi.org/10.1007/s00415-014-7509-2

    Article  PubMed  Google Scholar 

  3. 3.

    Lynch DS, Jaunmuktane Z, Sheerin U, Phadke R, Brandner S, Milonas I, Dean A, Bajaj N, McNicholas N, Costello D, Cronin S, McGuigan C, Rossor M, Fox N, Murphy E, Chataway J, Houlden H (2016) Hereditary leukoencephalopathy with axonal spheroids: a spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series. J Neurol Neurosurg Psychiatry 87:512–519. https://doi.org/10.1136/jnnp-2015-310788

    Article  Google Scholar 

  4. 4.

    Lakshmanan R, Adams ME, Lynch DS, Kinsella JA, Phadke R, Schott JM, Murphy E, Rohrer JD, Chataway J, Houlden H, Fox NC, Davagnanam I (2017) Redefining the phenotype of ALSP and AARS2 mutation-related leukodystrophy. Neurol Genet 3(2):e135. https://doi.org/10.1212/NXG.0000000000000135

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Michael Bayat.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The case report been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

The patient has consented to the submission of this case report to the journal.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bayat, M., Shekhrajka, N. & Bayat, A. Hereditary leukodystrophy with axonal spheroids (HDLS) presenting subacutely: a CNS-vasculitis mimic. Acta Neurol Belg 119, 633–635 (2019). https://doi.org/10.1007/s13760-019-01096-5

Download citation