Skip to main content
SpringerLink
Log in

Factors associated with deterioration of health-related quality of life in multiple system atrophy: 1-year follow-up study

  • Original Article
  • Published:
Acta Neurologica Belgica Aims and scope Submit manuscript

Abstract

The aim of this study was to identify the main contributors to the health-related quality of life (HRQoL) in multiple system atrophy with predominant parkinsonism (MSA-P) and to determine the usefulness of SF-36 in capturing the HRQoL changes over 1-year follow-up. A total of 45 MSA-P and 150 Parkinson’s disease (PD) patients were studied. The hierarchical multiple regression analysis was conducted to identify predictors of the SF-36 total score. The magnitude of any change for the HRQoL over 1-year of follow-up, was calculated as an effect size. The average scores for each SF-36 domains, except for the bodily pain, were lower in MSA-P than in PD patients (p < 0.05). The most important predictors of HRQoL in MSA-P, were female gender, older age at onset, SCOPA-AUT score and UMSARS IV, which together with other selected clinical variables accounted for 84% of the variance in the total SF-36 score in the final model in hierarchical analyses. During the 1-year follow-up, the SF 36 was found capable of detecting changes in MSA-P. Our study provided some new insights into potential predictors of the HRQoL and its longitudinal changes in MSA-P, which should be considered when healthcare programs are developed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fanciulli A, Wenning G (2015) Multiple-system atrophy. N Engl J Med 372:249–263

    Article  Google Scholar 

  2. May S, Gilman S, Sowell BB et al (2007) Potential outcome measures and trial design issues for multiple system atrophy. Mov Disord 22(16):2371–2377

    Article  Google Scholar 

  3. Schrag A, Geser F, Stampfer-Kountchev M et al (2006) Health-related quality of life in multiple system atrophy. Mov Disord 21(6):809–815

    Article  Google Scholar 

  4. Calvert M, Pall H, Hoppitt T, Eaton B, Savill E, Sackley C (2013) Health-related quality of life and supportive care in patients with rare long-term neurological conditions. Qual Life Res 22(6):1573–2649

    Article  Google Scholar 

  5. Köllensperger M, Stampfer-Kountchev M, Seppi K et al (2007) Progression of dysautonomia in multiple system atrophy: A prospective study of self-perceived impairment. Eur J Neurol 14(1):66–72

    Article  Google Scholar 

  6. Gilman S, Low P, Quinn N, Albanese A et al (1998) Consensus statement on the diagnosis of multiple system atrophy. American Autonomic Society and American Academy of Neurology. Clin Auton Res 8(6):359–362

    Article  CAS  Google Scholar 

  7. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184

    Article  CAS  Google Scholar 

  8. SF-36 Health Survey (Original version) Language Recalls. http://www.qualitymetric.com. Accessed Jan 2018

  9. Hoehn M, Yahr M (1967) Parkinsonism: onset, progression, and mortality. Neurology 57(2):318–334

    Article  Google Scholar 

  10. Fahn S, Elton RL, Members of the UPDRS Development Committee (1987) Unified Parkinson’s disease rating scale. In: Fahn S, Goldstein M, Calne DB (eds) Recent developments in Parkinson’s disease II. MacMillan, New York, pp 153–163

    Google Scholar 

  11. Wenning GK, Tison F, Seppi K et al (2004) Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Mov Disord 19(12):1391–1402

    Article  Google Scholar 

  12. Hamilton MC (1960) Hamilton Depression Rating Scale (HAM-D). Redloc 23:56–62

    CAS  Google Scholar 

  13. Hamilton M (1959) Hamilton Anxiety Rating Scale (HAM-A). J Med 61(4):81–82

    Google Scholar 

  14. Starkstein SE, Mayberg SE, Preziosi TJ et al (1992) Reliability, validity, and clinical correlates of apathy in Parkinson’s disease. J Neuropsychiatry Clin Neurosci 4(2):134–139

    Article  CAS  Google Scholar 

  15. Cummings JL, Mega M, Gray K et al (1994) The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44:2308–2314

    Article  CAS  Google Scholar 

  16. Mioshi E, Dawson K, Mitchell J et al (2006) The Addenbrooke’s cognitive examination revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry 21(11):1078–1085

    Article  Google Scholar 

  17. Dubois B, Slachevsky A, Litvan I, Pillon B (2000) The FAB: a frontal assessment battery at bedside. Neurology 55(11):1621–1626

    Article  CAS  Google Scholar 

  18. Visser M, Marinus J, Stiggelbout AM et al (2004) Assessment of autonomic dysfunction in Parkinson’s disease: the SCOPA-AUT. Mov Disord 19(11):1306–1312

    Article  Google Scholar 

  19. Ware JE, Snow KK, Kosinski M, Gandek B (1993) SF-36 health survey manual and interpretation guide. New England Medical Center, Boston

    Google Scholar 

  20. Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Academic Press, New York

    Google Scholar 

  21. Schrag A, Sheikh S, Quinn NP et al (2010) A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy. Mov Disord 25(8):1077–1081

    Article  Google Scholar 

  22. Winter Y, Spottke AE, Stamelou M et al (2011) Health-related quality of life in multiple system atrophy and progressive supranuclear palsy. Neurodegener Dis 8(6):438–446

    Article  Google Scholar 

  23. Kass-Iliyya L, Kobylecki C, Mcdonald KR et al (2015) Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson’s disease. Brain Behav 5(5):2–5

    Article  Google Scholar 

  24. Colosimo C, Morgante L, Antonini A et al (2010) Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study. J Neurol 257(1):5–14

    Article  Google Scholar 

  25. Benrud-Larson LM, Sandroni P, Schrag A, Low PA (2005) Depressive symptoms and life satisfaction in patients with multiple system atrophy. Mov Disord 20(8):951–957

    Article  Google Scholar 

  26. Pekmezovic T, Jecmenica-Lukic M, Petrovic I et al (2015) Quality of life in patients with progressive supranuclear palsy: one-year follow-up. J Neurol 262(9):2042–2048

    Article  Google Scholar 

  27. Meissner WG, Foubert-Samier A, Dupouy S et al (2012) Assessment of quality of life with the multiple system atrophy health-related quality of life scale. Mov Disord 27(12):1574–1577

    Article  Google Scholar 

  28. Wenning GK, Geser F, Krismer F et al (2013) The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 12(3):264–274

    Article  Google Scholar 

Download references

Acknowledgements

This work has been funded by the Ministry of Education, Science and Technological Development Republic of Serbia (Project no. 175090).

Author information

Authors and Affiliations

  1. Clinic of Neurology, School of Medicine, University of Belgrade, Ul. Dr Subotića 6, Belgrade, 11000, Serbia

    Milica V. Jecmenica-Lukic, Tatjana D. Pekmezovic, Igor N. Petrovic, Natasa T. Dragasevic & Vladimir S. Kostić

  2. Institute of Epidemiology, School of Medicine, University of Belgrade, Belgrade, Serbia

    Tatjana D. Pekmezovic

Authors
  1. Milica V. Jecmenica-Lukic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatjana D. Pekmezovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Igor N. Petrovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Natasa T. Dragasevic
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vladimir S. Kostić
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vladimir S. Kostić.

Ethics declarations

Conflict of interest

MJL declare no conflict of interests. TP reports grants from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project nos. 175087 and 175090). IP has received speaker honoraria from GlaxoSmithKline, Boehringer Ingelheim, and El pharma. ND has received speaker honoraria from Boehringer Ingelheim. VK receives research support from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project no. 175090) and Serbian Academy of Sciences and Arts, as well as research grants from Stada, Valeant, Boehringer Ingelheim, and Novartis.

Ethical standard

The research presented in this study was approved by local Ethics Committees. The authors declare that they acted in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Informed consent

Informed consent was obtained from each patient prior to their inclusion in this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jecmenica-Lukic, M.V., Pekmezovic, T.D., Petrovic, I.N. et al. Factors associated with deterioration of health-related quality of life in multiple system atrophy: 1-year follow-up study. Acta Neurol Belg 118, 589–595 (2018). https://doi.org/10.1007/s13760-018-0962-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13760-018-0962-4

Keywords

Search

Navigation