Acta Neurologica Belgica

, Volume 118, Issue 2, pp 201–210 | Cite as

Parkinson’s disease and risk of hip fracture: systematic review and meta-analysis

  • Ali Hosseinzadeh
  • Malahat Khalili
  • Behnaz Sedighi
  • Sohrab Iranpour
  • Ali Akbar Haghdoost


The relationship between Parkinson’s disease (PD) and risk of hip fracture yielded inconsistent results. Therefore, we conducted the present systematic review and meta-analysis of published observational studies to assess the association between PD and risk of hip fracture. PubMed, ISI, EMBASE, and Cochrane databases were searched systematically to identify studies assessing the relationship between PD and the risk of hip fracture up to July 01, 2017. In addition, to find related articles, the reference section of retrieved articles was checked. Random-effects model was used for calculation of pooled hazard ratio (HR) and 95% confidence intervals (CI). Thirteen independent studies containing 564,947 participants were included in the meta-analysis. The overall results of included studies showed PD to be associated with the risk of hip fracture (HRoverall = 3.13, 95% CI 2.53–3.87) in women 3.11 (2.51–3.86) and men 2.60 (2.19–3.09). Our meta-analysis showed the direct association between PD and the risk of hip fracture in both men and women. However, due to the limitations of this study, further well-designed studies are required to confirm our findings.


Parkinson’s disease Hip fracture Meta-analysis Risk factor 


Compliance with ethical standards

Conflict of interest

Ali Hosseinzadeh, Malahat Khalili, Behnaz Sedighi, Sohrab Iranpour, and Ali Akbar Haghdoost declare that they have no conflict of interest. The authors alone are responsible for the content and writing of this paper.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© Belgian Neurological Society 2018

Authors and Affiliations

  • Ali Hosseinzadeh
    • 1
  • Malahat Khalili
    • 1
  • Behnaz Sedighi
    • 2
  • Sohrab Iranpour
    • 3
  • Ali Akbar Haghdoost
    • 1
  1. 1.Research Center for Modeling in Health, Institute for Future Studies in HealthKerman University of Medical SciencesKermanIran
  2. 2.Department of Neurology, Shafa HospitalKerman University of Medical ScienceKermanIran
  3. 3.Department of EpidemiologyShahid Beheshti University of Medical SciencesTehranIran

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