Evaluation of thickness of retinal nerve fiber layer, ganglion cell layer, and choroidal thickness in essential tremor: can eyes be a clue for neurodegeneration?
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The pathology of essential tremor (ET) and underlying mechanisms of the disease are still unclear, but an increasing amount of research has been conducted on the subject. Discussions are ongoing about ET’s definition as a neurodegenerative disease. Optic coherence tomography (OCT) provides a window to the brain where direct visualization of central nervous system (CNS) changes may be possible, and it can help us to develop a new point of view on ET. The goal of this study was to examine OCT parameters in ET. 40 ET patients and 40 healthy controls, i.e., a total of 160 eyes were evaluated. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid thinning were analyzed using spectral domain OCT. The mean age was 25.77 ± 8.98 in the ET group and 27.25 ± 8.22 in the control group. We found a decreased global RNFL thickness for both eyes in ET patients. All GCL and IPL thickness parameters were lower in the patients with ET (P < 0.001, P 0.03). Choroid was significantly thicker in ET patients than the controls (P < 0.001). Our study’s results suggest that the usefulness of OCT in detecting neurodegeneration in ET. RNFL, GCL, IPL measurements are highly reproduced findings of neurodegeneration. Increased choroid volume may indicate neuroinflammation. Eyes in ET may shed light on nature of the disease, and may be used as a diagnostic tool.
KeywordsOptic coherence tomography Essential tremor Retinal nerve fiber layer Ganglion cell layer Choroidal thickness
We thank Psy. Hakan Serdar Sengul and Dr. Neslihan Cevik for their valuable contribution.
Compliance with ethical standards
There was no funding source in this study.
Conflict of interest
The authors declare that there is no conflict of interest.
The study was conducted in accordance with the ethical principles stated in the “Declaration of Helsinki” and was approved by the Ethical Committee of the Adıyaman University Hospital.
Informed consent was obtained from the participants after the nature of the procedures had been fully explained.
- 9.Sengul Y, Sengul HS, Yucekaya SK, Yucel S, Bakim B, Pazarcı NK, Özdemir G (2015) Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor. Acta Neurol Belg 115:281–287. doi: 10.1007/s13760-014-0396-6 CrossRefPubMedGoogle Scholar
- 21.Sengul Y, Sengul HS, Yucekaya SK, Yucel S, Bakim B, Pazarcı NK, Özdemir G (2015) Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor. Acta Neurol Belg 115(3):281–287. doi: 10.1007/s13760-014-0396-6 (Epub 2014 Dec 5) CrossRefPubMedGoogle Scholar
- 27.Turkel Y, Ornek N, Dag E, Ornek K, Alpua M, Ogurel T, Olmez Y (2015) Retinal nerve fiber layer thickness in patients with essential tremor. Neurol Asia 20(4):363–366Google Scholar
- 28.Kaleagasi H, Fidanci H, Adiguzel U, Dogu O (2015) Evaluation of retinal nerve fiber layer in essential tremor and Parkinson’s disease with optical coherence tomography. Mov Disord 30:4190Google Scholar
- 31.Serbecic N, Aboul-Enein F, Beutelspacher SC, Vass C, Kristoferitsch W, Lassmann H, Reitner A, Schmidt-Erfurth U (2011) High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years. PLoS One 6:5. doi: 10.1371/journal.pone.0019843.e19843 CrossRefGoogle Scholar
- 33.Talman LS, Bisker ER, Sackel DJ, Long DA Jr, Galetta KM, Ratchford JN, Lile DJ, Farrell SK, Loguidice MJ, Remington G, Conger A, Frohman TC, Jacobs DA, Markowitz CE, Cutter GR, Ying G, Dai Y, Maguire MG, Galetta SL, Frohman EM, Calabresi PA, Balcer LJ (2010) Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis. Ann Neurol 67:749–760. doi: 10.1002/ana.22005 PubMedPubMedCentralGoogle Scholar
- 40.Albrecht P, Müller AK, Südmeyer M, Ferrea S, Ringelstein M, Cohn E, Aktas O, Dietlein T, Lappas A, Foerster A, Hartung HP, Schnitzler A, Methner A (2012) Optical coherence tomography in parkinsonian syndromes. PLoS One 7:e34891. doi: 10.1371/journal.pone.0034891 CrossRefPubMedPubMedCentralGoogle Scholar
- 44.Larrosa JM, Garcia-Martin E, Bambo MP, Pinilla J, Polo V, Otin S, Satue M, Herrero R, Pablo LE (2014) Potential new diagnostic tool for Alzheimer’s disease using a linear Discriminant function for Fourier domain optical coherence tomography. Invest Ophthalmol Vis Sci 55:3043–3051. doi: 10.1167/iovs.13-13629 CrossRefPubMedGoogle Scholar
- 48.González-López JJ, Rebolleda G, Leal M, Oblanca N, Munoz-Negrete FJ, Costa-Frossard L, Álvarez-Cermeño José C (2014) Comparative diagnostic accuracy of ganglion cell-inner plexiform and retinal nerve fiber layer thickness measures by Cirrus and Spectralis optical coherence tomography in relapsing-remitting multiple sclerosis. Biomed Res Int 43:1–10. doi: 10.1155/2014/128517 CrossRefGoogle Scholar
- 49.Garcia-Martin E, Polo V, Larrosa JM, Marques ML, Herrero R, Martin J, Ara JR, Fernandez J, Pablo LE (2014) Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography. Ophthalmology 121:573–579. doi: 10.1016/j.ophtha.2013.09.035 CrossRefPubMedGoogle Scholar
- 51.Cheung CY, Ong YT, Hilal S, Ikram MK, Low S, Ong YL, Venketasubramanian N, Yap P, Seow D, Chen CL, Wong TY (2015) Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 45:45–56. doi: 10.3233/JAD-141659 PubMedGoogle Scholar
- 54.Eraslan M, Cerman E, YildizBalci S, Celiker H, Sahin O, Temel A, Suer D, Tuncer Elmaci N (2016) The choroid and lamina cribrosa is affected in patients with Parkinson’s disease: enhanced depth imaging optical coherence tomography study. Acta Ophthalmol 94:68–75. doi: 10.1111/aos.12809 CrossRefGoogle Scholar