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Determination of the Genetic and Synergistic Suppression of a Methoxyfenozide-Resistant Strain of the House Fly Musca domestica L. (Diptera: Muscidae)

  • Pest Management
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A Correction to this article was published on 03 May 2018

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Abstract

Musca domestica Linnaeus (house fly, Diptera: Muscidae) is a major veterinary and medical important pest all over the world. These flies have ability to develop resistance to insecticides. The present trial was performed to discover the inheritance mode (autosomal, dominance, number of genes involved) and preliminary mechanism of methoxyfenozide resistance in order to provide basic information necessary to develop resistance management strategy for this pest. A strain of M. domestica (MXY-SEL) was exposed to methoxyfenozide for 44 generations which developed a 5253.90-fold level of resistance to methoxyfenozide. The overlapping fiducial limits of LC50 values of the reciprocal crosses, F1 (MXY-SEL ♂ × Susceptible ♀) and F1† (MXY-SEL ♀ × Susceptible ♂), suggest that inheritance of methoxyfenozide resistance was an autosomal and likely completely dominant trait (DLC = 0.93 and 0.94 for F1 and F1†, respectively). Backcrosses of the F1 with the parental MXY-SEL or Susceptible population predict a polygenic mode of inheritance. Piperonyl butoxide significantly altered the LC50 values, suggesting enhanced detoxification by cytochrome P450-dependent monooxygenases is a major mechanism of resistance to methoxyfenozide in the MXY-SEL strain. The estimated realized heritability was 0.07 for methoxyfenozide. These results would be helpful for the better management of M. domestica.

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Change history

  • 03 May 2018

    Due to an unfortunate turn of events, the surname of the last author appeared incorrectly in the original publication as the name should have read Binyameen.

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Acknowledgments

The authors are highly grateful to Prof. (Rtd.) Dr. Gerald Wilde and Prof. Dr. R. Jeff Whitworth, Kansas State University, USA, for the critical review of the manuscript to improve English language.

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Authors and Affiliations

  1. Dept of Entomology, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya Univ, Multan, Pakistan

    R M Shah, N Abbas, S A Shad & M Binyamin

  2. Dept of Entomology, Univ College of Agriculture and Environmental Sciences, The Islamia Univ of Bahawalpur, Bahawalpur, Pakistan

    N Abbas

  3. Faculty of Forestry and Wood Sciences, EXTEMIT-K, Czech Univ of Life Sciences, Suchdol, Czech Republic

    M Binyamin

  4. Department of Entomology, Chemical Ecology Laboratory, Penn State University, University Park, PA, USA

    M Binyamin

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  1. R M Shah
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  2. N Abbas
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Correspondence to N Abbas.

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Edited by Pedro Takao Yamamoto – ESALQ/USP

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Shah, R.M., Abbas, N., Shad, S.A. et al. Determination of the Genetic and Synergistic Suppression of a Methoxyfenozide-Resistant Strain of the House Fly Musca domestica L. (Diptera: Muscidae). Neotrop Entomol 47, 709–715 (2018). https://doi.org/10.1007/s13744-018-0604-9

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