Skip to main content
SpringerLink
Log in

A Zn(II)–organic framework: fluorescent turn-on detection of Al3+, treatment and nursing application on glioma by inducing the cancer cell death

  • Original Paper
  • Published:
Journal of the Iranian Chemical Society Aims and scope Submit manuscript

Abstract

In the current study, a novel Zn(II)-MOF with the chemical formula of {[Zn2(TPTA)(1,4-bib) (H2O)4]·2CH3OH}n (1) has been synthesized by solvothermal reaction of Zn(NO3)2·6H2O, 1,4-bis(1-imidazoly) benzene (1,4-bib) and 2′- amino-[1,1′,4′,1"- terphenyl]-3,3",5,5"-tetracarboxylic acid (H4TPTA), and its chemical formula is {[Zn(TPTA)0.5(1,4-bib)0.5(H2O)2]·CH3OH}n (1). Noticeably, complex 1 has been proved to be useful for fluorescent detection of Al3+ based on a fluorescent turn-on performance. Using the microcrystalline samples of 1, the very low limits of detection (LODs) for the Al3+ ion can be up to 30 nM. The bioactivity of the compound to glioma was assessed, and the relevant mechanism was discussed. In addition to experimental findings, results provided by the molecular docking showed that both functional groups exhibited interactions with protein.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

Data availability

The data used to support the findings of this study are included within the article.

References

  1. R. Chen, M. Smith-Cohn, A.L. Cohen, H. Colman, Neurotherapeutics 14, 284 (2017)

    Article  Google Scholar 

  2. S.A. Grimm, M.C. Chamberlain, Curr. Neurol. Neurosci. Rep. 13, 346 (2013)

    Article  Google Scholar 

  3. O. Gusyatiner, M.E. Hegi, Semin. Cancer Biol. 51, 50 (2018)

    Article  CAS  Google Scholar 

  4. D.K. Singha, P. Mahata, Inorg. Chem. 54, 6373 (2015)

    Article  CAS  Google Scholar 

  5. D.M. Chen, N.N. Zhang, C. Sen Liu, M. Du, J. Mater. Chem. C 5, 2311 (2017)

    Article  CAS  Google Scholar 

  6. N. Jiang, Y. Liu, X.N. Yu, H.B. Zhang, M.M. Wang, Int. J. Electrochem. Sci. 15, 5520 (2020)

    Article  CAS  Google Scholar 

  7. C.P. Li, W.W. Long, Z. Lei, L. Guo, M.J. Xie, J. Lü, X.D. Zhu, Chem. Commun. 56, 12403 (2020)

    Article  CAS  Google Scholar 

  8. K. Wu, J. Hu, S. Shi, J. Li, X. Cheng, Dye. Pigment. 173, 107993 (2020)

    Article  CAS  Google Scholar 

  9. J. Zhao, J. Zhang, D. Zhang, Z. Hu, Y. Sun, Sci. Total Environ. 752, 141932 (2021)

    Article  CAS  Google Scholar 

  10. R. Sen, A. Halder, D. Ghoshal, Polyhedron 183, 114534 (2020)

    Article  CAS  Google Scholar 

  11. C. Duan, L. Dong, F. Li, Y. Xie, B. Huang, K. Wang, Y. Yu, H. Xi, Ind. Eng. Chem. Res. 59, 18857 (2020)

    Article  CAS  Google Scholar 

  12. Y. Ge, B. Teng, L. Lv, R. Chen, B. Wu, Cryst. Growth Des. 20, 486 (2020)

    Article  CAS  Google Scholar 

  13. G.C. Liu, Y. Li, J. Chi, N. Xu, X.L. Wang, H.Y. Lin, Y.Q. Chen, Dye. Pigment. 174, 108064 (2020)

    Article  CAS  Google Scholar 

  14. L.N. Zheng, F.H. Wei, H.M. Hu, C. Bai, X.L. Yang, X. Wang, G. Xue, Polyhedron 161, 47 (2019)

    Article  CAS  Google Scholar 

  15. F. Rouhani, F. Rafizadeh-Masuleh, A. Morsali, J. Mater. Chem. A 35, 454 (2019)

    Google Scholar 

  16. W. Xie, W.W. He, S.L. Li, K.Z. Shao, Z.M. Su, Y.Q. Lan, Chem. A Eur. J. 22, 17298 (2016)

    Article  CAS  Google Scholar 

  17. Y. Hu, M. Ding, X.Q. Liu, L.B. Sun, H.L. Jiang, Chem. Commun. 52, 5734 (2016)

    Article  CAS  Google Scholar 

  18. J. Wang, Y. Li, M. Jiang, Y. Liu, L. Zhang, P. Wu, Chem. A Eur. J. 22, 13023 (2016)

    Article  CAS  Google Scholar 

  19. M.B. Tucker, S.H. MacKenzie, J.J. Maciag, H.D. Ackerman, P. Swartz, J.A. Yoder, P.T. Hamilton, A.C. Clark, Protein Sci. 25, 2076 (2016)

    Article  CAS  Google Scholar 

  20. R. Lv, Z. Chen, X. Fu, B. Yang, H. Li, J. Su, W. Gu, X. Liu, J. Solid State Chem. 259, 67 (2018)

    Article  CAS  Google Scholar 

  21. Y. Liu, C. Liu, X. Zhang, L. Liu, C. Ge, X. Zhuang, N. Zhang, Q. Yang, Y.Q. Huang, Z. Zhang, J. Solid State Chem. 272, 1 (2019)

    Article  CAS  Google Scholar 

  22. S. Yao, X. Tian, L. Li, S. Liu, T. Zheng, Y. Chen, D. Zhang, J. Chen, H. Wen, T. Hu, Chem. Asian J. 14, 3648 (2019)

    Article  CAS  Google Scholar 

  23. S. Goldar, M.S. Khaniani, S.M. Derakhshan, B. Baradaran, Asian Pac. J. Cancer Prev. 16, 2129 (2015)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurosurgery Department, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China

    Ze Zhou & Yan-Guo Zhang

Authors
  1. Ze Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yan-Guo Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yan-Guo Zhang.

Ethics declarations

Conflict of interest

The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 1665 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, Z., Zhang, YG. A Zn(II)–organic framework: fluorescent turn-on detection of Al3+, treatment and nursing application on glioma by inducing the cancer cell death. J IRAN CHEM SOC 18, 2189–2195 (2021). https://doi.org/10.1007/s13738-021-02187-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13738-021-02187-y

Keywords

Search

Navigation