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Metal-free greener method for the synthesis of densely functionalized pyrroles via a one-pot three-component reaction

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Abstract

A convenient and straightforward acid-promoted synthesis of a new series of polyfunctionalized pyrroles has been developed based on a one-pot three-component reaction of acetoacetanilide, benzoin, and ammonium acetate/diverse anilines in acetic acid as a green solvent at 100 °C. The other salient benefits of this transformation include being simple reaction conditions, toxic transition-metal-free, no need of column chromatographic purification, moderate to good yields, eco-friendliness, and readily available starting materials.

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Acknowledgements

We gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

    Maryam Fatahpour, Nourallah Hazeri & Malek Taher Maghsoodlou

  2. Faculty of Science, Velayat University, Iranshahr, Iran

    Mojtaba Lashkari

Authors
  1. Maryam Fatahpour
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  2. Nourallah Hazeri
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  3. Malek Taher Maghsoodlou
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  4. Mojtaba Lashkari
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Correspondence to Nourallah Hazeri.

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Fatahpour, M., Hazeri, N., Maghsoodlou, M.T. et al. Metal-free greener method for the synthesis of densely functionalized pyrroles via a one-pot three-component reaction. J IRAN CHEM SOC 16, 111–116 (2019). https://doi.org/10.1007/s13738-018-1486-9

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  • DOI: https://doi.org/10.1007/s13738-018-1486-9

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