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Multivariate statistical design optimization for ultrasonic-assisted restricted access supramolecular solvent-based liquid phase microextraction of quercetin in food samples

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Abstract

In this method, quercetin as a flavonoid has been extracted, preconcentrated and determined by using ultrasonic-assisted restricted access supramolecular solvent-based liquid phase microextraction method in food samples. The quercetin concentration in extraction phase was determinated by UV–visible spectrophotometer which has microsampling cuvette. Multivariate statistical design approach was used to optimize the analytical variables including the pH, ratio of restricted access solvent components, volume of restricted access solvent, ultrasonication and centrifugation times. The analytical performance values of the developed method including limit of detection, limit of quantification, preconcentration factor and relative standard deviation (10 replicates of 10–5 M of quercetin solution) were found as 2.98, 9.93 μg L−1, 30 and 6.3%, respectively. The method provides important advantages such as use of minimum volume of organic solvents, simple and economical operation and easy optimization via multivariate statistical design approach. The developed procedure was validated with four food samples, and acceptable recoveries (87–104%) were achieved.

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Acknowledgements

Zainab Manzoor Memon is thankful to the Scientific and Technological Research Council of Turkey (TUBITAK) under “2216 Research Fellowship Programme for Foreign Citizens” for financial support.

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Authors and Affiliations

  1. Department of Chemistry Science Faculty, Erciyes University, 38039, Kayseri, Turkey

    Zainab Manzoor Memon, Erkan Yilmaz & Mustafa Soylak

  2. Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan

    Zainab Manzoor Memon

Authors
  1. Zainab Manzoor Memon
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  2. Erkan Yilmaz
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  3. Mustafa Soylak
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Correspondence to Mustafa Soylak.

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Memon, Z.M., Yilmaz, E. & Soylak, M. Multivariate statistical design optimization for ultrasonic-assisted restricted access supramolecular solvent-based liquid phase microextraction of quercetin in food samples. J IRAN CHEM SOC 14, 2521–2528 (2017). https://doi.org/10.1007/s13738-017-1187-9

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  • DOI: https://doi.org/10.1007/s13738-017-1187-9

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