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Synthesis of highly substituted cyclopentadienes containing quinoline nucleus

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Abstract

Synthesis of novel highly substituted cyclopentadienes containing quinoline nucleus is described. The initially prepared Knöevenagel adducts of 2-chloroquinoline-3-carbaldehydes and malononitrile or ethyl cyanoacetate underwent reaction with acetylenecarboxylates and isocyanide in dichloromethane at room temperature within 12 h, affording a variety of the desired products in moderate to good yields. Mild reaction condition, use of simple experimental procedure and prompt isolation of the products are some advantages of this protocol.

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Acknowledgments

The authors acknowledge the University of Tehran and Radioisotope Research Group of NSTRI for financial support of this research.

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Authors and Affiliations

  1. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran

    Mehdi Ghandi, Nahid Zarezadeh & Shahnaz Rahimi

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  1. Mehdi Ghandi
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  2. Nahid Zarezadeh
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  3. Shahnaz Rahimi
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Correspondence to Mehdi Ghandi.

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Ghandi, M., Zarezadeh, N. & Rahimi, S. Synthesis of highly substituted cyclopentadienes containing quinoline nucleus. J IRAN CHEM SOC 12, 1577–1584 (2015). https://doi.org/10.1007/s13738-015-0630-z

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  • DOI: https://doi.org/10.1007/s13738-015-0630-z

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