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Secondary bladder amyloidosis due to Crohn’s disease: a case report and literature review

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Abstract

The presence of amyloid deposits in bladder walls is a rare histological finding. It can be linked to primary (limited to bladder) or secondary (systemic, associated with chronic inflammatory disorders) amyloidosis. Secondary bladder involvement is very uncommon; it usually presents with gross hematuria, which is challenging to manage, due to frail bladder mucosa and/or necrosis. We present a case of 54-year old man with secondary bladder amyloidosis due to Crohn’s disease, that caused gross hematuria and severe anemia, which was managed conservatively by endoscopic transurethral resection, diatermocoagulation, clot evacuation and urinary drainage by bilateral percutaneous nephrostomy, with spontaneous resolution. Secondary bladder amyloidosis is a rare condition that presents with severe hematuria, difficult to control with standard management. Owing to chronic nature of the disease, treatment should be aimed to a conservative approach whenever possible. In case of failure, invasive procedures should be considered as salvage therapies.

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Authors and Affiliations

  1. Department of Urology, S. Orsola-Malpighi University Hospital, Via P. Palagi 9, 40138, Bologna, Italy

    Matteo Droghetti, Amelio Ercolino, Pietro Piazza, Lorenzo Bianchi, Federico Mineo Bianchi, Umberto Barbaresi, Carlo Casablanca, Elena Tonin, Angelo Mottaran, Riccardo Schiavina & Eugenio Brunocilla

  2. Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Cardio-Nephro-Thoracic Sciences Doctorate, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy

    Lorenzo Bianchi, Riccardo Schiavina & Eugenio Brunocilla

  3. Pathology Unit, S. Orsola-Malpighi University Hospital, Via Massarenti 9, 40138, Bologna, Italy

    Benedetta Fabbrizio, Francesca Giunchi & Michelangelo Fiorentino

Authors
  1. Matteo Droghetti
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  2. Amelio Ercolino
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  3. Pietro Piazza
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  4. Lorenzo Bianchi
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  5. Benedetta Fabbrizio
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  6. Francesca Giunchi
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  7. Federico Mineo Bianchi
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  9. Carlo Casablanca
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  10. Elena Tonin
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  13. Riccardo Schiavina
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  14. Eugenio Brunocilla
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Corresponding author

Correspondence to Matteo Droghetti.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies were conducted (IRB approval number 93/2012/U/Oss) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Droghetti, M., Ercolino, A., Piazza, P. et al. Secondary bladder amyloidosis due to Crohn’s disease: a case report and literature review. CEN Case Rep 9, 413–417 (2020). https://doi.org/10.1007/s13730-020-00497-3

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  • DOI: https://doi.org/10.1007/s13730-020-00497-3

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