CEN Case Reports

, Volume 7, Issue 2, pp 221–224 | Cite as

Measurement of urinary biomarkers in a case of tubulointerstitial nephritis and uveitis syndrome during glucocorticoid treatment

  • Masafumi SugiyamaEmail author
Case Report


Tubulointerstitial nephritis and uveitis (TINU) is a rare syndrome in which idiopathic interstitial nephritis coexists with chronic recurrent uveitis. This syndrome often represents systemic disorders such as arthralgia, rash, prolonged fever, anaemia and ocular symptoms that require medication including glucocorticoid administration. Recently, novel urinary biomarkers, such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and liver-type fatty acid-binding protein, were shown to be associated with tubulointerstitial damage and were elevated in interstitial nephritis. We evaluated these urinary biomarkers in a case of TINU syndrome before and during treatment and found that their levels were elevated at onset and decreased during treatment, especially NGAL. We conclude that these urinary biomarkers are useful to evaluate and predict prognosis in interstitial nephritis.


Kidney injury molecule-1 Liver-type fatty acid-binding protein Neutrophil gelatinase-associated lipocalin Urinary biomarkers Tubulointerstitial nephritis and uveitis syndrome 


Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest.

Research involving human participants and informed consent

Informed consent was obtained from all individual participants including in this case report.

Ethical standards

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.


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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  1. 1.Department of Nephrology and RheumatologyHashima Municipal HospitalGifuJapan

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