CEN Case Reports

, Volume 7, Issue 2, pp 195–197 | Cite as

Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome

  • T. Harish Varma
  • Ashish Sharma
  • S. Santhiya
  • Lesa Dawman
  • Karalanglin TiewsohEmail author
Case Report


Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome. It has minimal side effects on short-term usage, but prolonged use can result in polyuria, hypokalemia and metabolic alkalosis. This pseudo-bartter complication can be treated by discontinuation of the drug with adequate potassium replacement. We report a child who was given furosemide for 20 days elsewhere to treat the edema due to nephrotic syndrome and then presented to us with bartter-like syndrome. Furosemide was discontinued and potassium replacement was initiated. However, the child continued to have polyuria leading to repeated episodes of hypotensive shock. In view of severe symptoms, she was given a short course of oral indomethacin for 6 days, to which she responded. This case highlights the fact that indomethacin can provide symptomatic improvement in furosemide induced pseudo-bartter.


Furosemide Pseudo bartter syndrome Potassium Metabolic alkalosis Indomethacin 




Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Research involving human participants and/or animals

Due permission from the Departmental Review Board was taken.

Informed consent



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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  • T. Harish Varma
    • 1
  • Ashish Sharma
    • 1
  • S. Santhiya
    • 1
  • Lesa Dawman
    • 1
  • Karalanglin Tiewsoh
    • 1
    Email author
  1. 1.Department of PediatricsPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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