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CEN Case Reports

, Volume 7, Issue 1, pp 169–173 | Cite as

Influence of thyroid function on glomerular filtration rate and other estimates of kidney function in two pediatric patients

  • Osamu Uemura
  • Naoyuki Iwata
  • Takuhito Nagai
  • Satoshi Yamakawa
  • Satoshi Hibino
  • Masaki Yamamoto
  • Masaru Nakano
  • Kazuki Tanaka
Case Report
  • 92 Downloads

Abstract

To determine the optimal method of evaluating kidney function in patients with thyroid dysfunction, this study compared the estimated glomerular filtration rate derived from serum creatinine, cystatin C, or β2-microglobulin with inulin or creatinine clearance in two pediatric patients, one with hypothyroidism and the other with hyperthyroidism. It was observed that the kidney function decreased in a hypothyroid child and enhanced in a hyperthyroid child, with their kidney function becoming normalized by treatment with drugs, which normalized their thyroid function. Kidney function cannot be accurately evaluated using cystatin C-based or β2-microglobulin-based estimated glomerular filtration rate in patients with thyroid dysfunction, as these tests overestimated glomerular filtration rate in a patient with hypothyroidism and underestimated glomerular filtration rate in a patient with hyperthyroidism, perhaps through a metabolic rate-mediated mechanism. In both our patients, 24-h urinary creatinine secretion was identical before and after treatment, suggesting that creatinine production is not altered in patients with thyroid dysfunction. Therefore, kidney function in patients with thyroid dysfunction should be evaluated using creatinine-based estimated glomerular filtration rate.

Keywords

Hypothyroid Hyperthyroid Estimated glomerular filtration rate Creatinine Cystatin C β2-microglobulin 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

Informed consent of the patients involved was provided about the publication of this article.

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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  1. 1.Department of Pediatric NephrologyAichi Children’s Health and Medical CenterObuJapan
  2. 2.Department of Clinical MedicineJapanese Red Cross Toyota College of NursingToyotaJapan

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