Skip to main content

Advertisement

SpringerLink
Log in

Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report

  • Case Report
  • Published:
CEN Case Reports Aims and scope Submit manuscript

Abstract

Malignancies are one of the leading causes of death in long-term surviving transplant recipients. Dose and prolonged durations of immunosuppressive regimens are considered the main cause, through a direct oncogenic effect and a renowned interaction on physiological anti-viral and anti-oncogenic immune response. Specific neoplasms are known to occur with different frequencies according to the transplanted organ. As a consequence, imaging screenings have been implemented in many graft surveillance programs, although a wide consensus on the timing and modality has not been concurred. There are little data available in the literature regarding incidence of de-novo malignancies in multi-organ recipients. We report the case of a 66-year-old man who developed a renal mass 10 years after a combined heart–kidney transplant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Tsai H, Lee C, Kuo C, et al. De novo malignancy in organ transplant recipients in Taiwan : a nationwide cohort population study. Oncotarget. 2017;8(22):36685–95.

  2. Domhan S, Zeier M, Abdollahi A. Immunosuppressive therapy and post-transplant malignancy. Nephrol Dial Transpl. 2009;24:1097–103.

    Article  Google Scholar 

  3. Agraharkar ML, Cinclair RD, Kuo Y-F, et al. Risk of malignancy with long-term immunosuppression in renal transplant recipients. Kidney Int. 2017;66:383–9. https://doi.org/10.1111/j.1523-1755.2004.00741.x.

    Article  Google Scholar 

  4. Morris PJ. Transplantation–a medical miracle of the 20th century. N Engl J Med. 2004;351:2678–80. https://doi.org/10.1056/NEJMp048256.

    Article  CAS  PubMed  Google Scholar 

  5. Chapman JR, Webster AC, Wong G. Cancer in the transplant recipient. Cold Spring Harb Perspect Med. 2013;3:1–15. https://doi.org/10.1101/cshperspect.a015677.

    Article  Google Scholar 

  6. Campistol JM. Minimizing the risk of posttransplant malignancy. Transpl Proc. 2008;40:27–30. https://doi.org/10.1016/j.transproceed.2008.10.015.

    Article  Google Scholar 

  7. Webster AC, Craig JC, Simpson JM, et al. Identifying high risk groups and quantifying absolute risk of cancer after kidney transplantation: a cohort study of 15 183 recipients. Am J Transpl. 2007;7:2140–51. https://doi.org/10.1111/j.1600-6143.2007.01908.x.

    Article  CAS  Google Scholar 

  8. Engels EA, Pfeiffer RM, Fraumeni JF, et al. Spectrum of cancer risk among US solid organ transplant recipients. Jama. 2011;306:1891–901. https://doi.org/10.1001/jama.2011.1592.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Castello M, Gregorini M, Rampino T, et al. A retrospective analysis of dermatological lesions in kidney transplant patients. Indian J Med Res. 2013;137:1188–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. AlBugami M, Kiberd B. Malignancies: pre and post transplantation strategies. Transpl Rev. 2014;28:76–83. https://doi.org/10.1016/j.trre.2013.12.002.

    Article  Google Scholar 

  11. Végsö G, Toronyi É, Hajdu M, et al. Renal cell carcinoma of the native kidney: a frequent tumor after kidney transplantation with favorable prognosis in case of early diagnosis. Transpl Proc. 2011;43:1261–3. https://doi.org/10.1016/j.transproceed.2011.03.068.

    Article  Google Scholar 

  12. Kälble T, Lucan M, Nicita G, Sells R, Burgos Revilla FJ, Wiesel M. EAU guidelines on renal transplantation. Eur Urol. 2005;47(2):156–66.

  13. Frascà GM, Sandrini S, Cosmai L, et al. Renal cancer in kidney transplanted patients. J Nephrol. 2015;28:659–68. https://doi.org/10.1007/s40620-015-0219-8.

    Article  PubMed  Google Scholar 

  14. Kellerman L, Neugut A, Burke B, Mancini D. Comparison of the incidence of de novo solid malignancies after heart transplantation to that in the general population. Am J Cardiol. 2009;103:562–6. https://doi.org/10.1016/j.amjcard.2008.10.026.

    Article  PubMed  Google Scholar 

  15. Sánchez-Lázaro IJ, Almenar-Bonet L, Martínez-Dolz L, et al. Post-heart transplant tumors: chronology and impact on survival. Transpl Proc. 2010;42:3201–3. https://doi.org/10.1016/j.transproceed.2010.05.052.

    Article  Google Scholar 

  16. Almenar-Bonet L. Spanish heart transplantation registry. 18th official report of the Spanish society of cardiology working group on heart failure, heart transplantation and associated therapies (1984–2006). Rev Española Cardiol (English Ed). 2007;60:1177–87.

    Google Scholar 

  17. Roussel JC, Baron O, Périgaud C, et al. Outcome of heart transplants 15–20 years ago: graft survival, post-transplant morbidity, and risk factors for mortality. J Heart Lung Transpl. 2008;27:486–93. https://doi.org/10.1016/j.healun.2008.01.019.

    Article  Google Scholar 

  18. Lateef N, Basit KA, Abbasi N, et al. Malignancies after heart transplant. Exp Clin Transpl. 2016;14:12–6. https://doi.org/10.6002/ect.2015.0214.

    Google Scholar 

  19. Anthony C, Jabbour A, Kotlyar E, et al. A 25 year review of combined cardiac and renal transplant outcomes in patients with end stage cardiac failure on renal replacement therapy. A single center experience. J Heart Cardiol. 2016;2:1–9. https://doi.org/10.15436/2378-6914.16.021.

    Google Scholar 

  20. Bacchi G, Potena L, Mosconi G, et al. Combined heart-kidney transplantation: a single center experience. Open J Organ Transpl Surg. 2011;1:14–8. https://doi.org/10.4236/ojots.2011.12003.

    Article  Google Scholar 

  21. Awad M, Czer LSC, Esmailian F, et al. Combined heart and kidney transplantation: a 23-year experience. Transpl Proc. 2017;49:348–53. https://doi.org/10.1016/j.transproceed.2016.11.040.

    Article  CAS  Google Scholar 

  22. López-Sainz A, Barge-Caballero E, Paniagua-Martin MJ, et al. Clinical characteristics and long-term outcomes of patients undergoing combined heart-kidney transplantation: a single-center experience. Transpl Proc. 2015;47:123–6. https://doi.org/10.1016/j.transproceed.2014.11.009.

    Article  Google Scholar 

  23. Vermes E, Grimbert P, Sebbag L, et al. Long-term results of combined heart and kidney transplantation: a French multicenter study. J Heart Lung Transpl. 2009;28:440–5. https://doi.org/10.1016/j.healun.2009.01.020.

    Article  Google Scholar 

  24. Hevia V, Gomez V, Diez Nicolas V, et al. Development of urologic de novo malignancies after renal transplantation. Transpl Proc. 2014;46:170–5. https://doi.org/10.1016/j.transproceed.2013.12.004.

    Article  CAS  Google Scholar 

  25. Sun IO, Ko YM, Kim EY, et al. Clinical characteristics and outcomes in renal transplant recipients with renal cell carcinoma in the native kidney. Korean J Intern Med. 2013;28:347–51.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Kato T, Kakuta Y, Abe T, et al. The benefits of cancer screening in kidney transplant recipients: a single-center experience. Cancer Med. 2016;5:153–8. https://doi.org/10.1002/cam4.568.

    Article  PubMed  Google Scholar 

  27. La Fianza A, Pellegrini C, Berton F, et al. Diagnostic imaging of lung cancer after heart transplantation. Tumori. 2006;92:429–32.

    PubMed  Google Scholar 

  28. Goh A, Vathsala A. Native renal cysts and dialysis duration are risk factors for renal cell carcinoma in renal transplant recipients. Am J Transpl. 2011;11:86–92. https://doi.org/10.1111/j.1600-6143.2010.03303.x.

    Article  CAS  Google Scholar 

  29. Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transpl 2009, 9(Suppl 3), pp. S1–155. https://doi.org/10.1111/j.1600-6143.2009.02834.x.

  30. Ambrosi P, Bertucci F, Kreitmann B. High incidence of asymptomatic renal cancer in late survivors after heart transplantation. J Heart Lung Transpl. 2011;30:1202–3. https://doi.org/10.1016/j.healun.2011.05.003.

    Article  Google Scholar 

  31. Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010;102:605–13. https://doi.org/10.1093/jnci/djq099.

    Article  PubMed  Google Scholar 

  32. Acuna SA, Fernandes KA, Daly C, et al. Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada. JAMA Oncol. 2016;2:1–8. https://doi.org/10.1001/jamaoncol.2015.5137.

    Article  Google Scholar 

  33. European Best Practice Guidelines for Renal Transplantation. Section IV.1 Organization of follow-up of transplant recipients after the first year. Nephrol Dial Transplant. 2002;17(Suppl 4):3–4. https://doi.org/10.1093/ndt/17.suppl_4.3-a.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Radiology, IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy

    Matteo Paoletti, Giovanni Gentile & Alfredo La Fianza

  2. Department of Cardiac Surgery, IRCCS Policlinico San Matteo, Viale Golgi 19, 27100, Pavia, Italy

    Barbara Cattadori, Andrea Maria D’Armini & Carlo Pellegrini

  3. Nephrology, Dialysis and Transplant Unit, IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy

    Marilena Gregorini

  4. Department of Pathology, IRCCS Policlinico San Matteo; University of Pavia, Viale Golgi 19, 27100, Pavia, Italy

    Alessandra Viglio

  5. School of “Cardiovascular Pathophysiology, Cardiac Perfusion”, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy

    Andrea Maria D’Armini & Carlo Pellegrini

  6. Chair of Cardiac Surgery, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy

    Andrea Maria D’Armini & Carlo Pellegrini

Authors
  1. Matteo Paoletti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Barbara Cattadori
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marilena Gregorini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alessandra Viglio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giovanni Gentile
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Andrea Maria D’Armini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Carlo Pellegrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alfredo La Fianza
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matteo Paoletti.

Ethics declarations

Conflict of interest

All the authors have declared no competing interests.

Human participants and animal rights statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from the patient included in this article.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Paoletti, M., Cattadori, B., Gregorini, M. et al. Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report. CEN Case Rep 7, 132–136 (2018). https://doi.org/10.1007/s13730-018-0310-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13730-018-0310-9

Keywords

Search

Navigation