CEN Case Reports

, Volume 7, Issue 1, pp 34–38 | Cite as

A case of acute kidney injury caused by granulomatous interstitial nephritis associated with sarcoidosis

  • Taro Horino
  • Tatsuki Matsumoto
  • Kosuke Inoue
  • Osamu Ichii
  • Yoshio Terada
Case Report

Abstract

Sarcoidosis affects multiple organs including lung, heart and kidney. Sarcoidosis causes hypercalcemia, hypergammaglobulinemia, and rarely, granulomatous interstitial nephritis, resulting in renal stromal damage. Granulomatous interstitial nephritis is characterized as interstitial nephritis with noncaseating epithelioid granulomas. Diagnosing granulomatous interstitial nephritis before patient’s death is challenging; hence, only few cases proven by renal biopsy have been reported till date. We present a case of acute kidney injury caused by granulomatous interstitial nephritis as a renal manifestation of sarcoidosis proven by renal biopsy, which can be confirmed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Glucocorticoid therapy was helpful for improving and maintaining her renal function over a 6-year period.

Keywords

Acute kidney injury Granulomatous interstitial nephritis 18F-FDG-PET/CT Sarcoidosis 

Notes

Compliance with ethical standards

Conflict of interest

We have no conflicts of interest to declare.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

13730_2017_287_MOESM1_ESM.ppt (2.5 mb)
Pathohistological findings of renal biopsy. The renal biopsy specimen showing interstitial nephritis with noncaseating epithelioid granuloma, which is consistent with granulomatous interstitial nephritis. No other remarkable glomerular lesions were noted. (A: periodic acid-Schiff, × 100) (PPT 2553 KB)

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Copyright information

© Japanese Society of Nephrology 2017

Authors and Affiliations

  1. 1.Department of Endocrinology, Metabolism and NephrologyKochi Medical SchoolKochiJapan
  2. 2.Department of Biomedical Sciences, Laboratory of Anatomy, Graduate School of Veterinary MedicineHokkaido UniversitySapporoJapan

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