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A case of renal dysfunction caused by pelvic organ prolapse

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Abstract

Pelvic organ prolapse (POP) is the descent of pelvic organs through the vagina, and sometimes causes hydronephrosis. Although the association between POP and hydronephrosis has long been recognized, severe hydronephrosis and renal dysfunction are rarely seen. We report a case of 66-year-old woman who had a vaginal delivery presented with externalized uterine and bladder prolapse during the previous 2 years. She had a 3-day history of hypophagia and vomiting, and laboratory analysis resulted in serum creatinine of 5.75 mg/dL and blood urea of 78.1 mg/dL. The patient was treated urgently with vaginal pessary to return the uterine and bladder into the pelvis. After 2 weeks, her serum creatinine dropped to 3.66 mg/dL, but chronic renal failure persisted. Hydronephrosis caused by POP may lead to renal dysfunction and can advance to irreversible renal damage if left untreated. Important is early evaluation of renal function and images of the kidney and ureter.

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References

  1. Costantini E, Lazzeri M, Mearini L, Zucchi A, Del Zingaro M, Porena M. Hydronephrosis and pelvic organ prolapse. Urology. 2009;73(2):263–7.

    Article  Google Scholar 

  2. Gerten KA, Markland AD, Lloyd LK, Richter HE. Prolapse and incontinence surgery in older women. J Urol. 2008;179(6):2111–8.

    Article  Google Scholar 

  3. Altok M, Feyzullah ŞA, Umul M, Güneş M. Severe hydronephrosis caused by uterine prolapse with non pecific symptoms and normal renal function. Int J Women’s Health Reproduction Sci. 2013;1(3):111–4.

    Article  Google Scholar 

  4. Kong MK, Bai SW. Surgical treatments for vaginal apical prolapse. Obstet Gynecol Sci. 2016;59(4):253–60.

    Article  Google Scholar 

  5. Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet. 2007;369(9566):1027–38.

    Article  Google Scholar 

  6. Slieker-ten Hove MC, Pool-Goudzwaard AL, Eijkemans MJ, Steegers-Theunissen RP, Burger CW, Vierhout ME. Symptomatic pelvic organ prolapse and possible risk factors in a general population. Am J Obstet Gynecol. 2009;200(2):184.e1–7.

    Article  Google Scholar 

  7. Beverly CM, Walters MD, Weber AM, Piedmonte MR, Ballard LA. Prevalence of hydronephrosis in patients undergoing surgery for pelvic organ prolapse. Obstet Gynecol. 1997;90(1):37–41.

    Article  CAS  Google Scholar 

  8. Gemer O, Bergman M, Segal S. Prevalence of hydronephrosis in patients with genital prolapse. Eur J Obstet Gynecol Reprod Biol. 1999;86(1):11–3.

    Article  CAS  Google Scholar 

  9. Leanza V, Ciotta L, Vecchio R, Zanghì G, Maiorana A, Leanza G. Hydronephrosis and utero-vaginal prolapse in postmenopausal women: management and treatment. G Chir. 2015;36(6):251–6.

    CAS  PubMed  Google Scholar 

  10. ACOG Committee on Practice Bulletins–Gynecology. Obstet Gynecol. 2007;110(3):717–29.

    Article  Google Scholar 

  11. Bump RC, Mattiasson A, Bø K, Brubaker LP, DeLancey JO, Klarskov P, Shull BL, Smith AR. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996;175(1):10–7.

    Article  CAS  Google Scholar 

  12. Brettauer J, Rubin IC. Hydroureter and hydronephrosis: a frequent secondary finding in cases of prolapse of the uterus and bladder. Am J Obstet Gynecol. 1923;6:696–708.

    Article  Google Scholar 

  13. Kurt S, Guler T, Canda MT, Demirtas Ö, Tasyurt A. Treatment of uterine prolapse with bilateral hydronephrosis in a young nulliparous woman; a new minimally invasive extraperitoneal technique. Eur Rev Med Pharmacol Sci. 2014;18(11):1657–60.

    CAS  PubMed  Google Scholar 

  14. Melser M, Miles BJ, Kastan D, Shetty PC, Anderson W. Chronic renal failure secondary to post-hysterectomy vaginal prolapse. Urology. 1991;38(4):361–3.

    Article  CAS  Google Scholar 

  15. Klahr S, Morrissey J. Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol. 2002;283:F861–F875

    Article  Google Scholar 

  16. Vaughan ED Jr, Gillenwater JY. Recovery following complete chronic unilateral ureteral occlusion: functional, radiographic and pathologic alterations. J Urol. 1971;106(1):27–35.

    Article  Google Scholar 

  17. Shokeir AA, Provoost AP, Nijman RJ. Recoverability of renal function after relief of chronic partial upper urinary tract obstruction. BJU Int. 1999;83(1):11–7.

    Article  CAS  Google Scholar 

  18. Lamers BH, Broekman BM, Milani AL. Pessary treatment for pelvic organ prolapse and health-related quality of life: a review. Int Urogynecol J. 2011;22(6):637–44.

    Article  Google Scholar 

  19. Ellington DR, Richter HE. Indications, Contraindications, and Complications of Mesh in Surgical Treatment of Pelvic Organ Prolapse. Clin Obstet Gynecol. 2013;56(2):276–88.

    Article  Google Scholar 

  20. Chevalier RL, Thornhill BA, Wolstenholme JT. Renal cellular response to ureteral obstruction: role of maturation and angiotensin II. Am J Physiol. 1999;277(1 Pt 2):F41–7.

    Google Scholar 

  21. Jones EA, Shahed A, Shoskes DA. Modulation of apoptotic and inflammatory genes by bioflavonoids and angiotensin II inhibition in ureteral obstruction. Urology. 2000;56(2):346–51.

    Article  CAS  Google Scholar 

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Correspondence to Ai Miyagi.

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Miyagi, A., Inaguma, Y., Tokoyoda, T. et al. A case of renal dysfunction caused by pelvic organ prolapse. CEN Case Rep 6, 125–128 (2017). https://doi.org/10.1007/s13730-017-0257-2

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  • DOI: https://doi.org/10.1007/s13730-017-0257-2

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