Four cases of Trousseau syndrome associated with breast cancer that exhibited central nervous system manifestations


Cancer-associated thrombosis is known as Trousseau syndrome (TS). Here, we report 4 cases of TS associated with advanced breast cancer that caused central nervous system (CNS) vascular events. All 4 patients experienced sudden onset of CNS symptoms. Imaging revealed multiple brain infarctions or intracranial hemorrhage and all 4 patients had leptomeningeal or brain metastasis. Laboratory findings showed hypercoagulability at diagnosis of TS. Of the 4 patients, 2 patients were treated with unfractionated heparin, while 2 patients could not undergo anticoagulant therapy. In all patients, once the TS occurred, the CNS symptoms progressed rapidly and the prognosis was very poor, 3 patients dying within about a month of diagnosis of TS. Therefore, the predictive factors of TS are important and standards and guidelines for administration of anticoagulants are needed.

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We thank Tomas D Mayers, Medical English Communications Center, University of Tsukuba, for excellent English proofreading.

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Correspondence to Hiroko Bando.

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Okazaki, M., Bando, H., Ichioka, E. et al. Four cases of Trousseau syndrome associated with breast cancer that exhibited central nervous system manifestations. Int Canc Conf J 9, 146–150 (2020).

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  • Breast cancer
  • Venous thromboembolism
  • Trousseau syndrome