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A case of the cirrhotic patient performed living donor liver transplantation after carbon-ion radiotherapy for hepatocellular carcinoma

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Abstract

The patient was a 50-year-old female with an initial diagnosis of a single hepatocellular carcinoma in liver cirrhosis. The tumor was located in the posterior liver segment (S7) and measured 5 cm with a rapid growth rate and portal invasion. The pre-treatment Child-Pugh (C-P) was grade A (six points). The total prescribed dose of carbon-ion radiotherapy (C-ion RT) was 60 Gy (relative biological effectiveness) given in 4 fractions. Thereafter, tumor shrinkage and rapid decrease of the serum alpha-fetoprotein level were observed. At 1-year follow-up a new lesion was diagnosed in the left lobe and the underlying liver failure had worsened to C-P grade B (eight points). Thus, she was recommended to undergo living-donor liver transplantation (LDLT). The postoperative course was uneventful. At pathological examination, no viable tumor cells in the region treated with C-ion RT were detected. At the time of the last follow-up, the patient was in overall good general condition with no signs of tumor recurrence.

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Authors and Affiliations

  1. Ion Beam Therapy Center, SAGA HIMAT Foundation, Tosu, Japan

    Shingo Toyama, Yoshiyuki Shioyama, Hiroaki Suefuji, Makoto Shinoto, Keiji Matsumoto & Kotaro Terashima

  2. Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Masaaki Hidaka & Susumu Eguchi

  3. Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Kuniko Abe

  4. Department of Radiology, Faculty of Medicine, Saga University, Saga, Japan

    Hiroyuki Irie

  5. Liver Center, Saga University Hospital, Saga, Japan

    Yuichiro Eguchi

Authors
  1. Shingo Toyama
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  2. Yoshiyuki Shioyama
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  3. Hiroaki Suefuji
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  4. Makoto Shinoto
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  5. Keiji Matsumoto
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  6. Kotaro Terashima
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  7. Masaaki Hidaka
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  8. Susumu Eguchi
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  9. Kuniko Abe
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  10. Hiroyuki Irie
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  11. Yuichiro Eguchi
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Corresponding author

Correspondence to Shingo Toyama.

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The authors declare that they have no conflict of interest.

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Toyama, S., Shioyama, Y., Suefuji, H. et al. A case of the cirrhotic patient performed living donor liver transplantation after carbon-ion radiotherapy for hepatocellular carcinoma. Int Canc Conf J 7, 65–70 (2018). https://doi.org/10.1007/s13691-018-0322-5

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  • DOI: https://doi.org/10.1007/s13691-018-0322-5

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