A case of the cirrhotic patient performed living donor liver transplantation after carbon-ion radiotherapy for hepatocellular carcinoma

  • Shingo Toyama
  • Yoshiyuki Shioyama
  • Hiroaki Suefuji
  • Makoto Shinoto
  • Keiji Matsumoto
  • Kotaro Terashima
  • Masaaki Hidaka
  • Susumu Eguchi
  • Kuniko Abe
  • Hiroyuki Irie
  • Yuichiro Eguchi
Case report

Abstract

The patient was a 50-year-old female with an initial diagnosis of a single hepatocellular carcinoma in liver cirrhosis. The tumor was located in the posterior liver segment (S7) and measured 5 cm with a rapid growth rate and portal invasion. The pre-treatment Child-Pugh (C-P) was grade A (six points). The total prescribed dose of carbon-ion radiotherapy (C-ion RT) was 60 Gy (relative biological effectiveness) given in 4 fractions. Thereafter, tumor shrinkage and rapid decrease of the serum alpha-fetoprotein level were observed. At 1-year follow-up a new lesion was diagnosed in the left lobe and the underlying liver failure had worsened to C-P grade B (eight points). Thus, she was recommended to undergo living-donor liver transplantation (LDLT). The postoperative course was uneventful. At pathological examination, no viable tumor cells in the region treated with C-ion RT were detected. At the time of the last follow-up, the patient was in overall good general condition with no signs of tumor recurrence.

Keywords

Carbon-ion radiotherapy Hepatocellular carcinoma Living-donor liver transplantation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Japan Society of Clinical Oncology 2018

Authors and Affiliations

  • Shingo Toyama
    • 1
  • Yoshiyuki Shioyama
    • 1
  • Hiroaki Suefuji
    • 1
  • Makoto Shinoto
    • 1
  • Keiji Matsumoto
    • 1
  • Kotaro Terashima
    • 1
  • Masaaki Hidaka
    • 2
  • Susumu Eguchi
    • 2
  • Kuniko Abe
    • 3
  • Hiroyuki Irie
    • 4
  • Yuichiro Eguchi
    • 5
  1. 1.Ion Beam Therapy Center, SAGA HIMAT FoundationTosuJapan
  2. 2.Department of SurgeryNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  3. 3.Department of PathologyNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  4. 4.Department of Radiology, Faculty of MedicineSaga UniversitySagaJapan
  5. 5.Liver CenterSaga University HospitalSagaJapan

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