Abstract
Mucosa-associated lymphoid tissue (MALT) lymphomas arise from various anatomic sites, mostly observed in the gastrointestinal tract; however, involvement of the kidney is extremely rare. We report a case of MALT lymphoma involving the kidney in a 70-year-old man. Radical nephrectomy was performed under the diagnosis of renal cell carcinoma preoperatively. However, the renal specimen showed that the diffuse small- to medium-sized lymphocytes were scattered and formed colonies, and the neoplastic lymphoid cells were positive for CD20, CD79α, and Bcl-2, but negative for CD10 and Cyclin D1; therefore, the final histological diagnosis was MALT lymphoma involving the renal pelvis. Although he was referred to the department of hematology, no additional treatment was given postoperatively, and he has survived for 4 months without evidence of a recurrence of lymphoma at the last follow-up. To the best of our knowledge, to date 37 reports of MALT lymphoma involving the kidney have been published in the literature. We report a case of MALT lymphoma involving the kidney, and review the existing literature.
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References
Isaacson P, Wright DH (1983) Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B cell lymphoma. Cancer 52:1410–1416
Parveen T, Navarro-Roman L, Medeiros LJ et al (1993) Low-grade B cell lymphoma of mucosa-associated lymphoid tissue arising in the kidney. Arch Pathol Lab Med 117:780–783
Pelstring RJ, Essell JH, Kurtin PJ et al (1991) Diversity of organ site involvement among malignant lymphomas of mucosa-associated lymphoid tissues. Am J Clin Pathol 96:738–745
Olszewski AJ, Castillo JJ (2013) Survival of patients with marginal zone lymphoma: analysis of the surveillance, epidemiology, and end results database. Cancer 119:629–638
Okuno SH, Hoyer JD, Ristow K et al (1995) Primary renal non-Hodgkin’s lymphoma: an unusual extranodal site. Cancer 75:2258–2261
Yasunaga Y, Hoshida Y, Hashimoto M et al (1997) Malignant lymphoma of the kidney. J Surg Oncol 64:207–211
Qiu L, Unger PD, Dillon RW et al (2006) Low-grade mucosa-associated lymphoid tissue lymphoma involving the kidney: report of 3 cases and review of the literature. Arch Pathol Lab Med 130:86–89
Harris NL, Jaffe ES, Stein H et al (1994) A revised European-American classification of lymphoid neoplasm: a proposal from the international study group. Blood 84:1361–1392
Freeman C, Berg JW, Culter SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260
Ganeshan D, Iyer R, Devine C et al (2013) Imaging of primary and secondary renal lymphoma. Am J Roentgenol 201:W712–W719
Hoffmann M, Wohrer S, Becherer A et al (2006) 18F-Fluoro-deoxy-glucose positron emission tomography in lymphoma of mucosa-associated lymphoid tissue: histology makes the difference. Ann Oncol 17:1761–1765
Zukotynski K, Lewis A, O’Regan K et al (2012) PET/CT and renal pathology: a blind spot for radiologists? Part 2, lymphoma, leukemia, and metastatic disease. Am J Roentgenol 199:W168–W174
Jaffe ES, Harris NL, Stein H, Vardman JS (2008) Tumours of Hematologic and Lymphoid Tissues 2007. 4th ed. Lyon: IARC Press; 2008. World Health Organization. Classification of Tumours. Pathology and Genetics
Thieblemont C (2005) Clinical presentation and management of marginal zone lymphomas. Hematology Am Soc Hematol Educ Progr 1:307–313
Wagner JR, Honig SC, Siroky MB (1993) Non-Hodgkin’s lymphoma can mimic renal adenocarcinoma with inferior vena caval involvement. Urology 42:720–723
Garcia M, Konoplev S, Morosan C et al (2007) MALT lymphoma involving the Kidney. A reportof 10 cases and review of the literature. Am J Clin Pathol 128:464–473
Imahori SC (1994) Low-grade B cell lymphoma of mucosa-associated lymphoid tissue involving kidney. Arch Pathol Lab Med 118:111–112
Mak SK, Wong PN, Lo KY et al (1998) Successful treatment of IgA nephropathy in association with low-grade B cell lymphoma of the mucosa-associated lymphoid tissue type. Am J Kidney Dis 31:713–718
Kazuhiro A, Yoko K, Yoshiaki I et al (1998) Indolent behaviour of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue involving in salivary glands, renal sinus and prostate. Scand J Urol Nephrol 32:234–236
Colovic M, Hadzi-Djokic J, Cemerikic V et al (1999) Primary MALT lymphoma of the kidney. Hematol Cell Ther 41:229–232
Tao J, Kahn L (2000) Epstein-Barr virus-associated high-grade B cell lymphoma of mucosal-associated lymphoid tissue in a 9-year-old boy. Arch Pathol Lab Med 124:1520–1524
Mhawech P, Ahearn J, Medeiros LJ (2000) Pathologic quiz case: a unilateral renal mass in an elderly woman. Arch Pathol Lab Med 124:919–920
Jindal B, Sharma SC, Das A et al (2001) Indolent behaviour of low-grade B cell lymphoma of mucosa-associated lymphoid tissue arising in the kidney. Urol Int 67:91–93
Stokes MB, Wood B, Alpers CE (2002) Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin Nephrol 57:303–309
Mita K, Ohnishi Y, Edahiro T et al (2002) Primary mucosa-associated lymphoid tissue lymphoma in the renal pelvis. Urol Int 69:241–243
Tuzel E, Mungan MU, Yorukoglu K et al (2003) Primary renal lymphoma of mucosa-associated lymphoid tissue. Urology 61:463 (XVIII–XX)
Laven BA, Orvieto MA, Rapp DE et al (2004) Malignant B-cell lymphoma in renal cyst wall. Urology 64(590):e28–e29
Mortlock AM, Lim CSE, Morgan H et al (2006) Renal MALToma: an unusual lymphoma in a patient with lupus. Lupus 15:613–615
Kato Y, Hasegawa M, Numasato S et al (2008) Primary mucosa-associated lymphoid tissue-type lymphoma arising in the kidney. Int J Urol 15:90–92
Li B, Zhang W, Tian W et al (2008) Primary renal mucosa-associated lymphoid tissue lymphoma, the result of chronic pyelonephritis? Chinese-German. J Clin Oncol 7:55–58
Peces R, Vega-Cabrera C, Peces C et al (2010) MALT B cell lymphoma with kidney damage and monoclonal gammopathy: a case study and literature review. Nefrologia 30:681–686
Dedekam E, Graham J, Strenge K et al (2013) Primary renal lymphoma mimicking a subcapsular hematoma: a case report. J Radiol Case Rep 7:18–26
Otsuki H, Ito K, Sato K et al (2013) Malignant lymphoma of mucosa-associated lymphoid tissue involving the renal pelvis and the entire ureter: a case report. Oncol Lett 5:1625–1628
Chi PJ, Pei SN, Huang TL et al (2014) Renal MALT lymphoma associated with Waldenström macroglobulinemia. J Formos Med Assoc 113:255–257
Asgari SA, Aval HB, Asgari SA et al (2014) A unique case of kidney’s collecting system MALT lymphoma. Can Urol Assoc J 8:E172–E175
Niwa N, Tanaka N, Horinaga M et al (2014) Mucosa-associated lymphoid tissue lymphoma arising from the kidney. Can Urol Assoc J 8:E86–E88
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Makino, T., Miwa, S., Koshida, K. et al. Mucosa-associated lymphoid tissue lymphoma involving the kidney: a case report and review of the literature. Int Canc Conf J 5, 82–89 (2016). https://doi.org/10.1007/s13691-015-0234-6
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DOI: https://doi.org/10.1007/s13691-015-0234-6