Intestinal and Gastric Origins for Diabetes Resolution After Bariatric Surgery
Purpose of Review
This paper will review the intestinal and gastric origins for diabetes resolution after bariatric surgery.
In addition to the known metabolic effects of changes in the gut hormonal milieu, more recent studies investigating the role of the microbiome and bile acids and changes in nutrient sensing mechanisms have been shown to have glycemic effects in human and animal models.
Independent of weight loss, there are multiple mechanisms that may lead to amelioration or resolution of diabetes following bariatric surgery. There is abundant evidence pointing to changes in gut hormones, bile acids, gut microbiome, and intestinal nutrient sensing; more research is needed to clearly delineate their role in regulating energy and glucose homeostasis after bariatric surgery.
KeywordsBariatric surgery Type 2 diabetes Gut hormones Bile acids Gut microbiome
Compliance with Ethical Standards
Conflict of Interest
Caroline Andrew declares that she has no conflict of interest.
Devika Umashanker declares that she has no conflict of interest.
Louis J. Aronne has received consulting fees from and/has served on advisory boards for Jamieson Laboratories, Pfizer, Novo Nordisk, Eisai, GI Dynamics, Real Appeal, Janssen, United Health Group Ventures, and Gelesis; has received research funding from Aspire Bariatrics, Eisai, and AstraZeneca; has an equity interest in BMIQ, Zafgen, Gelesis, MYOS, and Jamieson Laboratories; and has served on a board of directors for MYOS, BMIQ and Jamieson Laboratories.
Alpana P. Shukla declares that she has no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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