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Current Dermatology Reports

, Volume 7, Issue 2, pp 91–98 | Cite as

What Is New in CTCL—Pathogenesis, Diagnosis, and Treatments

  • Brittany O. Dulmage
  • Betty Y. Kong
  • Kassandra Holzem
  • Joan Guitart
Skin Cancer (A Marghoob and M Marchetti, Section Editors)
  • 48 Downloads
Part of the following topical collections:
  1. Topical Collection on Skin Cancer

Abstract

Purpose of Review

Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin’s lymphoma primarily affecting the skin, of which mycosis fungoides (MF) and Sézary syndrome (SS) account for the majority of cases. The pathogenesis of CTCL is poorly understood with no strongly associated environmental or genetic risk factors identified to date. As such, the development of disease-specific therapies has been limited by a lack of understanding of potentially actionable targets. Moreover, the diagnosis of CTCL remains challenging with nonspecific diagnostic criteria, especially in early-stage disease.

Recent Findings

The advent of high-throughput sequencing techniques and molecular modalities has provided significant insight into disease pathogenesis, diagnosis, and potential therapies.

Summary

Here, we review the classic features of CTCL, focusing on MF/SS, and provide updates on our understanding of this disease.

Keywords

Cutaneous T cell lymphoma Mycosis fungoides Sézary syndrome T cell receptor Monoclonal antibody Checkpoint inhibitor 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Dulmage has a patent “Method for diagnosis, prognosis and determination of treatment for cutaneous t-cell lymphoma” pending.

Drs. Betty Y. Kong, Kassandra Holzem and Joan Guitart declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Brittany O. Dulmage
    • 1
  • Betty Y. Kong
    • 1
  • Kassandra Holzem
    • 1
  • Joan Guitart
    • 1
  1. 1.Department of DermatologyNorthwestern UniversityChicagoUSA

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