Skip to main content

Advertisement

Log in

Pelvic Pain in the Transgender Man

  • Care for the Transgender Patients (C Ferrando, Section Editor)
  • Published:
Current Obstetrics and Gynecology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this review is to update readers on the multifactorial nature of pelvic pain with specific considerations for the female to male (FtM) transgender patient.

Recent Findings

Secondary effects of testosterone therapy include both genital and musculoskeletal changes that may contribute to the development of pelvic pain. Hysterectomy is therapeutic for gender affirmation and underlying pain conditions. Postsurgical pain from further pelvic reconstruction may be the result of the reconstruction itself, surgical scarring, or prostheses.

Summary

Pelvic pain is a common condition with many contributing factors. For the FtM patient, pelvic pain may be present at any point in the transition process. Pain conditions may be pre-existing or occur as a result of medical or surgical treatment of gender dysphoria. Research is needed on sex hormone-specific influences on the development of pelvic pain and mitigation strategies for treatment-specific development of pelvic pain in the transgender population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Sorge RE, Totsch SK. Sex differences in pain. J Neurosci Res. 2017;95(6):1271–81.

    CAS  PubMed  Google Scholar 

  2. Girard-Tremblay L, Auclair V, Daigle K, Leonard G, Whittingstall K, Goffaux P. Sex differences in the neural representation of pain unpleasantness. J Pain. 2014;15(8):867–77.

    PubMed  Google Scholar 

  3. • Coleman E, Bockting W, Botzer M, Cohen-Kettenis P, DeCuypere G, Feldman J, et al. Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7. Int J Transgend. 2012;13(4):165–232 Comprehensive guidelines to provide evidence-based care in transgender health.

    Google Scholar 

  4. •• Obedin-Maliver J, Light A, de Haan G, Jackson RA. Feasibility of Vaginal Hysterectomy for Female-to-Male Transgender Men. Obstet Gynecol. 2017;129(3):457–63 This retrospective cohort study identified pelvic pain as the most common indication for hysterectomy for FtM.

    PubMed  Google Scholar 

  5. Iacovides S, Avidon I, Baker FC. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update. 2015;21(6):762–78.

    CAS  PubMed  Google Scholar 

  6. Janssen EB, Rijkers AC, Hoppenbrouwers K, Meuleman C, D'Hooghe TM. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update. 2013;19(5):570–82.

    CAS  PubMed  Google Scholar 

  7. ACOG Committee Opinion No. 760: dysmenorrhea and endometriosis in the adolescent. Obstet Gynecol. 2018;132(6):e249–e58.

  8. Latthe P, Latthe M, Say L, Gulmezoglu M, Khan KS. WHO systematic review of prevalence of chronic pelvic pain: a neglected reproductive health morbidity. BMC Public Health. 2006;6:177.

    PubMed  PubMed Central  Google Scholar 

  9. Proctor M, Farquhar C. Diagnosis and management of dysmenorrhoea. BMJ. 2006;332(7550):1134–8.

    PubMed  PubMed Central  Google Scholar 

  10. Sultan C, Gaspari L, Paris F. Adolescent dysmenorrhea. Endocr Dev. 2012;22:171–80.

    PubMed  Google Scholar 

  11. • Deutsch MB, Bhakri V, Kubicek K. Effects of cross-sex hormone treatment on transgender women and men. Obstet Gynecol. 2015;125(3):605–10 In this study, induction of amenorrhea occurred in 84% of patients 6 months after starting hormonal therapy.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Ferrero S, Gillott DJ, Venturini PL, Remorgida V. Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review. Reprod Biol Endocrinol. 2011;9:89.

    PubMed  PubMed Central  Google Scholar 

  13. Unger CA. Hormone therapy for transgender patients. Transl Androl Urol. 2016;5(6):877–84.

    PubMed  PubMed Central  Google Scholar 

  14. •• Deutsch MB. Guidelines for the primary and gender-affirming care of transgender and gender non-binary people. San Francisco: Center of Excellence for Transgender Health, Department of Family & Community Medicine, University of California, San Francisco. 2016; These guidelines have a specific chapter about the approach to pelvic pain in transgender men.

  15. Bofill Rodriguez M, Lethaby A, Grigore M, Brown J, Hickey M, Farquhar C. Endometrial resection and ablation techniques for heavy menstrual bleeding. Cochrane Database Syst Rev. 2019;1:CD001501.

    PubMed  Google Scholar 

  16. Thomassee MS, Curlin H, Yunker A, Anderson TL. Predicting pelvic pain after endometrial ablation: which preoperative patient characteristics are associated? J Minim Invasive Gynecol. 2013;20(5):642–7.

    PubMed  Google Scholar 

  17. Wortman M, Cholkeri A, McCausland AM, McCausland VM. Late-onset endometrial ablation failure--etiology, treatment, and prevention. J Minim Invasive Gynecol. 2015;22(3):323–31.

    PubMed  Google Scholar 

  18. Rachlin K, Hansbury G, Pardo ST. Hysterectomy and oophorectomy experiences of female-to-male transgender individuals. International Journal of Transgenderism. 2010;12(3):155–66.

    Google Scholar 

  19. Dennerstein L, Dudley EC, Hopper JL, Guthrie JR, Burger HG. A prospective population-based study of menopausal symptoms. Obstet Gynecol. 2000;96(3):351–8.

    CAS  PubMed  Google Scholar 

  20. Freeman EW, Sammel MD, Lin H, Gracia CR, Pien GW, Nelson DB, et al. Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstet Gynecol. 2007;110(2 Pt 1):230–40.

    PubMed  Google Scholar 

  21. • Chan KJ, Jolly D, Liang JJ, Weinand JD, Safer JD. Estrogen levels do not rise with testosterone treatment for transgender men. Endocr Pract. 2018;24(4):329–33 This article shows that transgender men on testosterone therapy have suppression of estrogen equivalent to levels in cisgender men.

    PubMed  Google Scholar 

  22. Miller N, Bedard YC, Cooter NB, Shaul DL. Histological changes in the genital tract in transsexual women following androgen therapy. Histopathology. 1986;10(7):661–9.

    CAS  PubMed  Google Scholar 

  23. Baldassarre M, Giannone FA, Foschini MP, Battaglia C, Busacchi P, Venturoli S, et al. Effects of long-term high dose testosterone administration on vaginal epithelium structure and estrogen receptor-alpha and -beta expression of young women. Int J Impot Res. 2013;25(5):172–7.

    CAS  PubMed  Google Scholar 

  24. Rahn DD, Good MM, Roshanravan SM, Shi H, Schaffer JI, Singh RJ, et al. Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial. J Clin Endocrinol Metab. 2014;99(10):3728–36.

    CAS  PubMed  PubMed Central  Google Scholar 

  25. • Winston MCpherson G, Long T, Salipante SJ, Rongitsch JA, Hoffman NG, Stephens K, et al. The vaginal microbiome of transgender men. Clin Chem. 2019;65(1):199–207 Vaginal flora of transgender men lack lactobacilli and may be associated with clinical symptoms.

    PubMed  Google Scholar 

  26. Perrone AM, Cerpolini S, Maria Salfi NC, Ceccarelli C, De Giorgi LB, Formelli G, et al. Effect of long-term testosterone administration on the endometrium of female-to-male (FtM) transsexuals. J Sex Med. 2009;6(11):3193–200.

    CAS  PubMed  Google Scholar 

  27. Futterweit W, Deligdisch L. Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals. J Clin Endocrinol Metab. 1986;62(1):16–21.

    CAS  PubMed  Google Scholar 

  28. Loverro G, Resta L, Dellino M, Edoardo DN, Cascarano MA, Loverro M, et al. Uterine and ovarian changes during testosterone administration in young female-to-male transsexuals. Taiwan J Obstet Gynecol. 2016;55(5):686–91.

    PubMed  Google Scholar 

  29. Baba T, Endo T, Honnma H, Kitajima Y, Hayashi T, Ikeda H, et al. Association between polycystic ovary syndrome and female-to-male transsexuality. Hum Reprod. 2007;22(4):1011–6.

    PubMed  Google Scholar 

  30. Grimstad FW, Fowler KG, New EP, Ferrando CA, Pollard RR, Chapman G, et al. Uterine pathology in transmasculine persons on testosterone: a retrospective multicenter case series. Am J Obstet Gynecol. 2019;220(3):257.e1–7.

    CAS  Google Scholar 

  31. Cloke B, Christian M. The role of androgens and the androgen receptor in cycling endometrium. Mol Cell Endocrinol. 2012;358(2):166–75.

    CAS  PubMed  Google Scholar 

  32. Reiter RC, Gambone JC. Nongynecologic somatic pathology in women with chronic pelvic pain and negative laparoscopy. J Reprod Med. 1991;36(4):253–9.

    CAS  PubMed  Google Scholar 

  33. Tu FF, As-Sanie S, Steege JF. Prevalence of pelvic musculoskeletal disorders in a female chronic pelvic pain clinic. J Reprod Med. 2006;51(3):185–9.

    PubMed  Google Scholar 

  34. •• Lamvu G, Carrillo J, Witzeman K, Alappattu M. Musculoskeletal Considerations in Female Patients with Chronic Pelvic Pain. Semin Reprod Med. 2018;36(2):107–15 This paper describes different musculoskeletal conditions leading to pelvic pain and has a detailed description on how to perform a complete musculoskeletal pelvic examination.

    PubMed  Google Scholar 

  35. Gebhart GF, Bielefeldt K. Physiology of visceral pain. Compr Physiol. 2016;6(4):1609–33.

    CAS  PubMed  Google Scholar 

  36. Cervero F. Visceral pain-central sensitisation. Gut. 2000;47 Suppl 4:iv56–7 discussion iv8.

    CAS  PubMed  Google Scholar 

  37. Cervero F. Visceral versus somatic pain: similarities and differences. Dig Dis. 2009;27(Suppl 1):3–10.

    PubMed  Google Scholar 

  38. Gyang A, Hartman M, Lamvu G. Musculoskeletal causes of chronic pelvic pain: what a gynecologist should know. Obstet Gynecol. 2013;121(3):645–50.

    PubMed  Google Scholar 

  39. Kind S, Otis JD. The interaction between chronic pain and PTSD. Curr Pain Headache Rep. 2019;23(12):91.

    PubMed  Google Scholar 

  40. •• Raja S, Hasnain M, Hoersch M, Gove-Yin S, Rajagopalan C. Trauma informed care in medicine: current knowledge and future research directions. Fam Community Health. 2015;38(3):216–26 This paper reviews the applicability and impact of the trauma-informed care pyramid in the clinical setting.

    PubMed  Google Scholar 

  41. Langenderfer-Magruder L, Whitfield DL, Walls NE, Kattari SK, Ramos D. Experiences of intimate partner violence and subsequent police reporting among lesbian, gay, bisexual, transgender, and queer adults in Colorado: comparing rates of cisgender and transgender victimization. J Interpers Violence. 2016;31(5):855–71.

    PubMed  Google Scholar 

  42. National Coalition of Anti-Violence Programs. Lesbian, gay, bisexual, transgender, queer, and HIV-affected intimate partner violence. 2013.

  43. Calton JM, Cattaneo LB, Gebhard KT. Barriers to help seeking for lesbian, gay, bisexual, transgender, and queer survivors of intimate partner violence. Trauma Violence Abuse. 2016;17(5):585–600.

    PubMed  Google Scholar 

  44. Cheatle MD. Biopsychosocial approach to assessing and managing patients with chronic pain. Med Clin North Am. 2016;100(1):43–53.

    PubMed  Google Scholar 

  45. Gatchel RJ, Peng YB, Peters ML, Fuchs PN, Turk DC. The biopsychosocial approach to chronic pain: scientific advances and future directions. Psychol Bull. 2007;133(4):581–624.

    PubMed  Google Scholar 

  46. •• U.S. Department of Health and Human Services. Pain management best practices Inter-Agency Task force report: updates, gaps, inconsistencies, and recommendations. Retrieved from US Department of Health and Human Services website: https://www.hhs.gov/ash/advisory-committees/pain/reports/index html. Accessed Dec. 2019. These national guidelines provide specific recommendations on how to approach chronic pain.

  47. Carrillo JL, Lamvu G. The Force is With You: Mind Tricks for Chronic Pelvic Pain. PWJ. 2019;7(4):36–43.

  48. James A, Thompson J, Neumann P, Briffa K. Change in pain knowledge occurring after a neuroscience education seminar for women with chronic pelvic pain. Australian & New Zealand Continence Journal. 2016;22(4).

  49. Choi BC, Pak AW. Multidisciplinarity, interdisciplinarity and transdisciplinarity in health research, services, education and policy: 1. Definitions, objectives, and evidence of effectiveness. Clin Invest Med. 2006;29(6):351–64.

    PubMed  Google Scholar 

  50. Gatchel RJ, McGeary DD, McGeary CA, Lippe B. Interdisciplinary chronic pain management: past, present, and future. Am Psychol. 2014;69(2):119–30.

    PubMed  Google Scholar 

  51. Nancarrow SA, Booth A, Ariss S, Smith T, Enderby P, Roots A. Ten principles of good interdisciplinary team work. Hum Resour Health. 2013;11:19.

    PubMed  PubMed Central  Google Scholar 

  52. •• Defreyne J, Elaut E, Kreukels B, Fisher AD, Castellini G, Staphorsius A, et al. Sexual desire changes in transgender individuals upon initiation of hormone treatment: results from the Longitudinal European Network for the Investigation of Gender Incongruence. J Sex Med. 2020; This survey noted persistent menstrual bleeding in transgender men is associated with decreased sexual desire.

  53. • Zoorob D, Higgins M, Swan K, Cummings J, Dominguez S, Carey E. Barriers to Pelvic Floor Physical Therapy Regarding Treatment of High-Tone Pelvic Floor Dysfunction. Female Pelvic Med Reconstr Surg. 2017;23(6):444–8 There are many barriers to performing pelvic floor physical therapy in cisgender women.

    PubMed  Google Scholar 

  54. Smith YL, Van Goozen SH, Kuiper AJ, Cohen-Kettenis PT. Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals. Psychol Med. 2005;35(1):89–99.

    PubMed  Google Scholar 

  55. Worldwide, AAGL Advancing Minimally Invasive Gynecology. AAGL position statement: route of hysterectomy to treat benign uterine disease. J Minim Invasive Gynecol. 2011;18(1):1–3.

  56. Committee Opinion No ACOG. 444: choosing the route of hysterectomy for benign disease. Obstet Gynecol. 2009;114(5):1156–8.

    Google Scholar 

  57. Bretschneider CE, Sheyn D, Pollard R, Ferrando CA. Complication rates and outcomes after hysterectomy in transgender men. Obstet Gynecol. 2018;132(5):1265–73.

    PubMed  Google Scholar 

  58. O'Hanlan KA, Dibble SL, Young-Spint M. Total laparoscopic hysterectomy for female-to-male transsexuals. Obstet Gynecol. 2007;110(5):1096–101.

    PubMed  Google Scholar 

  59. Bogliolo S, Cassani C, Babilonti L, Musacchi V, Nappi RE, Spinillo A. Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism. J Sex Med. 2014;11(1):313.

    PubMed  Google Scholar 

  60. Groenman F, Nikkels C, Huirne J, van Trotsenburg M, Trum H. Robot-assisted laparoscopic colpectomy in female-to-male transgender patients; technique and outcomes of a prospective cohort study. Surg Endosc. 2017;31(8):3363–9.

  61. Wierckx K, Van Caenegem E, Elaut E, Dedecker D, Van de Peer F, Toye K, et al. Quality of life and sexual health after sex reassignment surgery in transsexual men. J Sex Med. 2011;8(12):3379–88.

    PubMed  Google Scholar 

  62. Boskey ER, Cone RA, Whaley KJ, Moench TR. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum Reprod. 2001;16(9):1809–13.

    CAS  PubMed  Google Scholar 

  63. Soper DE. Bacterial vaginosis and surgical site infections. Am J Obstet Gynecol. 2020;222(3):219–23.

    CAS  PubMed  Google Scholar 

  64. McElligott KA, Havrilesky LJ, Myers ER. Preoperative screening strategies for bacterial vaginosis prior to elective hysterectomy: a cost comparison study. Am J Obstet Gynecol. 2011;205(5):500.e1–7.

    Google Scholar 

  65. Nikkels C, van Trotsenburg M, Huirne J, Bouman MB, de Leeuw R, van Mello N, et al. Vaginal Colpectomy in transgender men: a retrospective cohort study on surgical procedure and outcomes. J Sex Med. 2019;16(6):924–33.

    PubMed  Google Scholar 

  66. Gooren LJ. Management of female-to-male transgender persons: medical and surgical management, life expectancy. Curr Opin Endocrinol Diabetes Obes. 2014;21(3):233–8.

    PubMed  Google Scholar 

  67. Gomes da Costa A, Valentim-Lourenco A, Santos-Ribeiro S, Carvalho Afonso M, Henriques A, Ribeirinho AL, et al. Laparoscopic vaginal-assisted hysterectomy with complete Vaginectomy for female-to-male genital reassignment surgery. J Minim Invasive Gynecol. 2016;23(3):404–9.

    PubMed  Google Scholar 

  68. Monstrey SJ, Ceulemans P, Hoebeke P. Sex reassignment surgery in the female-to-male transsexual. Semin Plast Surg. 2011;25(3):229–44.

    PubMed  PubMed Central  Google Scholar 

  69. Nikolavsky D, Yamaguchi Y, Levine JP, Zhao LC. Urologic Sequelae following Phalloplasty in transgendered patients. Urol Clin North Am. 2017;44(1):113–25.

    PubMed  Google Scholar 

  70. Pigot GLS, Sigurjonsson H, Ronkes B, Al-Tamimi M, van der Sluis WB. Surgical experience and outcomes of implantation of the ZSI 100 FtM malleable penile implant in transgender men after Phalloplasty. J Sex Med. 2020;17(1):152–8.

    PubMed  Google Scholar 

  71. Neuville P, Morel-Journel N, Cabelguenne D, Ruffion A, Paparel P, Terrier JE. First outcomes of the ZSI 475 FtM, a specific prosthesis designed for phalloplasty. J Sex Med. 2019;16(2):316–22.

    PubMed  Google Scholar 

  72. Neuville P, Morel-Journel N, Maucourt-Boulch D, Ruffion A, Paparel P, Terrier JE. Surgical outcomes of erectile implants after phalloplasty: retrospective analysis of 95 procedures. J Sex Med. 2016;13(11):1758–64.

    PubMed  Google Scholar 

  73. Hage JJ, Bloem JJ, Bouman FG. Obtaining rigidity in the neophallus of female-to-male transsexuals: a review of the literature. Ann Plast Surg. 1993;30(4):327–33.

    CAS  PubMed  Google Scholar 

  74. Falcone M, Garaffa G, Gillo A, Dente D, Christopher AN, Ralph DJ. Outcomes of inflatable penile prosthesis insertion in 247 patients completing female to male gender reassignment surgery. BJU Int. 2018;121(1):139–44.

    CAS  PubMed  Google Scholar 

  75. Falcone M, Garaffa G, Raheem A, Christopher NA, Ralph DJ. Total phallic reconstruction using the radial artery based forearm free flap after traumatic penile amputation. J Sex Med. 2016;13(7):1119–24.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Janelle K. Moulder.

Ethics declarations

Conflict of Interest

Dr. Moulder reports personal fees from Hologic, outside the submitted work.

Dr. Carrillo reports personal fees from Abbvie, outside the submitted work.

Dr. Carey reports personal fees from Teleflex, personal fees from Med IQ, personal fees from MT ACOG, personal fees and other from Medical Expert in Surgery Litigation, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Care for the Transgender Patients

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Moulder, J.K., Carrillo, J. & Carey, E.T. Pelvic Pain in the Transgender Man. Curr Obstet Gynecol Rep 9, 138–145 (2020). https://doi.org/10.1007/s13669-020-00293-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13669-020-00293-x

Keywords

Navigation