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Antibiotische behandeling van infectieuze complicaties en urosepsis na een transrectale prostaatbiopsie of goudmarkerimplantatie

  • Behandeling van infect ie na prostaatbiopsie of goudmarkerimplantatie
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Samenvatting

Introductie:

In Nederland ontwikkelen jaarlijks naar schatting 1100 patiënten koorts na een prostaatbiopsie. Deze studie wil advies geven voor antibiotische behandeling van koorts na het nemen van transrectale prostaatbiopten of na transrectale goudmarkerimplantatie op basis van de gevonden resistentiepatronen.

Materiaal:

Patiënten bij wie een prostaatbiopsie of goudmarkerimplantatie is uitgevoerd vanaf 2008 tot en met 2011 werden onderzocht. Eén uur voor de ingreep werd ciprofloxacine ingenomen. Patiënten werden geïnstrueerd zich te melden bij koorts boven 38,5 °C. Patiënten met een positieve urine- en/of bloedkweek na de ingreep werden geïncludeerd.

Resultaten:

Er werden 1435 biopsieën of goudmarkerimplantaties verricht. Bij 40 verrichtingen (3,0%) werd een positieve kweek (18 bloed- en 30 urinekweken) gevonden met 27 maal (2,0%) een urosepsis. Resistentie inclusief intermediaire gevoeligheid voor ciprofloxacine, amoxicilline/clavulaanzuur en cotrimoxazol zijn respectievelijk 52%, 39% en 55%. Voor cefuroxim en tobramycine is dit respectievelijk 16% en 20%.

Conclusie:

Patiënten met koorts na het nemen van prostaatbiopten of na goudmarkerimplantatie zouden behandeld moeten worden met intraveneuze antibiotica.

Abstract

Summary

Antibiotic treatment of infectious complications and urosepsis after transrectal prostate biopsy and fiducial marker implantation.

Introduction:

In the Netherlands an estimated 1100 patient develop fever after prostate biopsies. This study gives advice on treatment of fever after transrectal prostate biopsies or transrectal fiducial marker implantation based on resistance patterns.

Materials:

Patients who underwent prostate biopsy or marker implantation between 2008 and 2011 were investigated. One hour before the procedure ciprofloxacin was administered orally. Patients were instructed to contact us when having fever above 38,5 °C. Patients with a positive culture after the procedure were included.

Results:

A total of 1435 procedures were performed. After 40 procedures (3,0%) a positive culture (18 blood- and 30 urine cultures) was found and after 27 procedures (2,0%) a urosepsis. Resistance plus intermediate sensitivity for ciprofloxacin, amoxicillin/clavulanic acid and cotrimoxazole were 52%, 39% and 55%, respectively. For cefuroxime and tobramycin these were 16% and 20%, respectively.

Conclusion:

Fever after prostate biopsy or marker implantation should be treated with intravenous antibiotics.

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Literatuur

  1. Casparie M, Tiebosch AT, Burger G, et al. Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive. Cell Oncol. 2007:29:19–24.

    PubMed  CAS  Google Scholar 

  2. Integraal kankercentrum Nederland. http://www.cijfersoverkanker.nl/meest-voorkomende-soorten-52.html.

  3. Carignan A, Roussy JF, Lapointe V, et al. Increasing risk of infectious complications after transrectal ultrasound-guided prostate biopsies: time to reassess antimicrobial prophylaxis? Eur Urol. 2012 Sep;62:453–9.

    Article  PubMed  Google Scholar 

  4. Loeb S, Heuvel S van den, Zhu X, et al. Infectious complications and hospital admissions after prostate biopsy in a European randomized trial. Eur Urol. 2012;61:1110–4.

    Article  PubMed  Google Scholar 

  5. Nam RK, Saskin R, Lee Y, et al. Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol. 2010;183:963–8.

    Article  PubMed  Google Scholar 

  6. Carlson WH, Bell DG, Lawen JG, et al. Multi-drug resistant E. coli urosepsis in physicians following transrectal ultrasound guided prostate biopsies - three cases including one death. Can J Urol. 2010;17:5135–7.

    PubMed  Google Scholar 

  7. Carmignani L, Picozzi S, Spinelli M, et al. Bacterial sepsis following prostatic biopsy. Int Urol Nephrol. 2012;44:1055–63.

    Article  PubMed  Google Scholar 

  8. Langenhuijsen JF, Lin ENJT van, Kiemeney LA, et al. Ultrasoundguided transrectal implantation of gold markers for prostate localization during external beam radiotherapy: complication rate and risk factors. Int J Radiat Oncol Biol Phys. 2007;69:671–6.

    Article  PubMed  Google Scholar 

  9. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–74.

  10. Eastham JA, Riedel E, Scardino PT, et al. Variation of serum prostate-specific antigen levels: an evaluation of year-to-year fluctuations. JAMA. 2003;289:2695–700.

    Article  PubMed  CAS  Google Scholar 

  11. Simsir A, Kismali E, Mammadov R, et al. Is it possible to predict sepsis, the most serious complication in prostate biopsy? Urol Int. 2010;84:395–9.

    Article  PubMed  Google Scholar 

  12. Patel U, Dasgupta P, Amoroso P, et al. Infection after transrectal ultrasonography-guided prostate biopsy: increased relative risks after recent international travel or antibiotic use. BJU Int. 2012;109:1781–5.

    Article  PubMed  Google Scholar 

  13. Taylor AK, Zembower TR, Nadler RB, et al. Targeted antimicrobial prophylaxis using rectal swab cultures in men undergoing transrectal ultrasound guided prostate biopsy is associated with reduced incidence of postoperative infectious complications and cost of care. J Urol. 2012 187:1275–9.

    Article  PubMed  CAS  Google Scholar 

  14. Thompson PM, Pryor JP, Williams JP, et al. The problem of infection after prostatic biopsy: the case for the transperineal approach. Br J Urol. 1982;54:736–40.

    Article  PubMed  CAS  Google Scholar 

  15. Vis AN, Boerma MO, Ciatto S, et al. Detection of prostate cancer: a comparative study of the diagnostic efficacy of sextant transrectal versus sextant transperineal biopsy. Urology. 2000;56:617–21.

    Article  PubMed  CAS  Google Scholar 

  16. Mutanga TF, Boer HC de, Wielen GJ van der, et al. Stereographic targeting in prostate radiotherapy: speed and precision by daily automatic positioning corrections using kilovoltage/megavoltage image pairs. Int J Radiat Oncol Biol Phys.2008 Jul 15;71:1074–83.

    Article  PubMed  Google Scholar 

  17. Moman MR, Heide UA van der, Kotte AN, et al. Long-term experience with transrectal and transperineal implantations of fiducial gold markers in the prostate for position verification in external beam radiotherapy; feasibility, toxicity and quality of life. Radiother Oncol. 2010;96:38–42..

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. afdeling Urologie, HagaZiekenhuis, Den Haag, The Netherlands

    G.J. van der Wielen,  O.E. van Rossum-Arguedas Flores,  J.A. Bellaar Spruyt &  F.M.J.A. Froeling

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  1. G.J. van der Wielen
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  2. O.E. van Rossum-Arguedas Flores
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  3. J.A. Bellaar Spruyt
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  4. F.M.J.A. Froeling
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Corresponding author

Correspondence to G.J. van der Wielen.

Additional information

* dr. G.J. van der Wielen, aios urologie

drs. O.E. van Rossum-Arguedas Flores, aios urologie

drs. J.A. Bellaar Spruyt, anios urologie

drs. F.M.J.A. Froeling, uroloog

Alle auteurs zijn verbonden aan het HagaZiekenhuis, afdeling Urologie.

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van der Wielen, G., van Rossum-Arguedas Flores, O., Bellaar Spruyt, J. et al. Antibiotische behandeling van infectieuze complicaties en urosepsis na een transrectale prostaatbiopsie of goudmarkerimplantatie. Tijdschrift voor Urologie 4, 134–138 (2014). https://doi.org/10.1007/s13629-014-0069-5

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  • DOI: https://doi.org/10.1007/s13629-014-0069-5

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