Abstract
One of the consequences of diabetes mellitus is deregulation in lipid metabolism, resulting in an increase in triglyceride and cholesterol levels in the blood. This study evaluated the effect of the Pycnoporus sanguineus hydroalcoholic extract on lipid metabolism in streptozotocin-induced diabetic rats. Rats received P. sanguineus extract for 4 weeks in the drinking water at a dose of 10 mg/Kg/day. Lipid profile, glucose and hepatic damage in normal and streptozotocin-induced diabetic rats were evaluated. Also, the chemical composition of P. sanguineus extract, cytotoxicity and HMG-CoA reductase activity in vitro were evaluated. The treatment significantly reduced triglyceride levels in the group of diabetic rats treated with the extract (DBT Pyc) compared to the group receiving water without extract (DBT H2O). For total cholesterol, reductions in the DBT Pyc group were also observed in relation to the DBT H2O group. The HMG-CoA reductase activity was not affected by P. sanguineus extract. Our findings demonstrated significant anti-hyperlipidaemic activity of P. sanguinues extract in diabetic rats. These results highlight the therapeutic potential of the P. sanguineus extract, which provides a new possibility for development of drugs to control hyperlipidaemia and provides impetus for further studies.
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Acknowledgements
GG and RCF cultivated the mushroom and prepared the extract. AF and ER realized the analysis of the chemical composition of the extract. MCVD and MPJ were responsible for the treatment of the animals and performed and interpretation of the biochemical analyzes and the hematological profile. MCVD was a major contributor in writing the manuscript. Critical revision of the article was done by E.R, MC, MPJ and MS. Conception, experimental design, overall monitoring and final approval of the article was done by ER, MC, MPS and MS. All authors read and approved the final manuscript. This work was supported by the Coordination of Improvement of Higher Education Personnel (CAPES) (Grant Number 3255/2013) and National Council for Scientific and Technological Development (CNPq) (Grant Number 472153/2013-7), and the University of Caxias do Sul (UCS).
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The research was approved by the Ethics Committee of Animal Use of the University of Caxias do Sul (013/2015) and was performed according to the international guidelines for performing studies on animals.
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Maiza Cristina Von Dentz has no conflict of interest. Gabriela Gambato has no conflict of interest. Andreza Ferrari has no conflict of interest. Roselei Claudete Fontana has no conflict of interest. Eliseu Rodrigues has no conflict of interest. Mirian Salvador has no conflict of interest. Marli Camassola has no conflict of interest. Matheus Parmegiani Jahn has no conflict of interest.
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Von Dentz, M., Gambato, G., Ferrari, A. et al. Antihyperlipidemic effect of the hydroalcoholic extract of Basidiomycete Pycnoporus sanguineus (Fr.) Murr. in streptozotocin-induced diabetic rats. ADV TRADIT MED (ADTM) 21, 453–461 (2021). https://doi.org/10.1007/s13596-020-00459-1
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DOI: https://doi.org/10.1007/s13596-020-00459-1