Skip to main content

Advertisement

SpringerLink
Log in

A literature-based phyto-pharmacological review on A. conchigera Griff

  • Review
  • Published:
Oriental Pharmacy and Experimental Medicine Aims and scope Submit manuscript

Abstract

This paper aims to sketch an up-to-date phyto-pharmacological reports on Alpinia conchigera Griff. For this, published scientific reports found in the databases: PubMed, Science Direct and Google Scholar were considered. The findings suggest that A. conchigera contains various important secondary metabolites, including alkaloids, steroids, flavonoids, saponins, triterpenes, and phenols. Rhizomes contain essential oils. A. conchigera possesses various important biological activities such as antioxidant, anti-inflammatory and membrane stabilizing, anti-microbial, anthelmintic, larvicidal, anti-diarrheal and anti-motility, anti-cancer, anti-nociceptive, sedative, pesticidal, melanin synthesis inhibitory, anti-pyretic, and anti-atherothrombosis effects. The anti-cancer effects of A. conchigera and its derivatives have been found by causing cytotoxicity, cell cycle arrest, apoptosis, autophagy and anti-proliferative effects in the test systems. Of note, A. conchigera may be one of the best sources of phytotherapeutic lead compounds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Box 1
Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Abdalla YOA, Nyamathulla S, Shamsuddin N, Arshad NM, Mun KS, Awang K, Nagoor NH (2018) Acute and 28-day sub-acute intravenous toxicity studies of 1′-S-1′-acetoxychavicol acetate in rats. Toxicol Appl Pharmacol 356(2018):204–213

    Article  CAS  PubMed  Google Scholar 

  • Adnan M, Bibi R, Mussarat S, Tariq A, Shinwari ZK (2014) Ethnomedicinal and phytochemical review of Pakistani medicinal plants used as antibacterial agents against Escherichia coli. Ann Clin Microbiol Antimicrob 13:40. https://doi.org/10.1186/s12941-014-0040-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aitadafoun M, Mounieri C, Heyman SF, Binistic C, Bon C, Godhold J (1996) 4-Alkoxybenzamides as new potent phosholipase A2 inhibitors. Biochem Pharmacol 51:737–742

    Article  Google Scholar 

  • Akram M, Hamid A, Khalil A, Ghaffar A, Tayyaba N, Saeed A et al (2014) Review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants. Int J Immunopathol Pharmacol 27(3):313–319

    Article  CAS  PubMed  Google Scholar 

  • Anita H, Mustafa AM, Ibrahim H (2000) Studies on essential oils of Alpinia conchigera Griff. from Malaysia. Malays J Sci 19:1–5

    Google Scholar 

  • Arshad NM, In LLA, Soh TL, Azmi MN, Ibrahim H, Awang K et al (2015) Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1′-S-1′-acetoxychavicol acetate when used as a complex against human tumours harbouring AFP-receptors. Oncogenetics 6(18):16151–16167

    Google Scholar 

  • Athamaprasangsa S, Buntrarongroj U, Dampawan P, Ongkavoranan N, Rukachaisirikul V, Sethuinda S et al (1994) A 1,7-diarylheptanoid from Alpinia conchigera. Phytochemistry 37(3):871–873

    Article  CAS  Google Scholar 

  • Awang K, Azmi MN, Aun LIL, Aziz AN, Ibrahim H, Nagoor NH (2010) The apoptotic effect of 1′S-1′-acetoxychavicol acetate from Alpinia conchigera on human cancer cells. Molecules 15:8048–8059

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aziz AN, Ibrahim H, Syamsir DR, Mohtar M, Vejayan J, Awang K (2013) Antimicrobial compounds from Alpinia conchigera. J Ethnopharmacol 145(2013):798–802

    Article  CAS  PubMed  Google Scholar 

  • Bhuiyan MNI, Chowdhury JU, Begum J, Nandi NC (2010) Essential oils analysis of the rhizomes of Alpinia conchigera Griff. and leaves of Alpinia malaccensis (Burm. f.) Roscoe from Bangladesh. Afr J Plant Sci 4(6):197–201

    CAS  Google Scholar 

  • Chen YF, Liu SY, Liang ZB, Lv MF, Zhou JN, Zhang LH (2016) Quorum sensing and microbial drug resistance. Yi Chuan 38(10):881–893

    PubMed  Google Scholar 

  • Dibyajyoti S, Swati P (2012a) Pharmacognostic studies of aerial part of methanolic extract of Alpinia conchigera Griff. Asian J Pharm Anal 2(2):46–48

    Google Scholar 

  • Dibyajyoti S, Swati P (2012b) In vitro screening of antifungal activity of methanol extract of Alpinia conchigera Griff. against some pathogenic species of fungi. Asian J Pharm Technol 2(2):44–46

    Google Scholar 

  • Dibyajyoti S, Swati P (2012c) Cytotoxic activity of methanolic extract of Alpinia conchigera Griff. (Family: Zingiberaceae). Asian J Pharm Res 2(2):86–88

    Google Scholar 

  • DuPont HL (2014) Acute infectious diarrhea in immunocompetent adults. N Engl J Med 370(16):1532–1540

    Article  CAS  PubMed  Google Scholar 

  • Ghazali AR, Hamzah F, Awang N, Razali WMW (2015) Toxicological profile of hexane extract of Alpinia conchigera (Small Ginger) in vitro. Malays J Health Sci 13(1):69–76

    Google Scholar 

  • Haque AKMM, Leong KH, Lo YL, Awang K, Nagoor NH (2017) In vitro inhibitory mechanisms and molecular docking of 1′-S-1′-acetoxychavicol acetate on human cytochrome P450 enzymes. Phytomedicine 31(2017):1–9

    Article  CAS  PubMed  Google Scholar 

  • Hasima NN, Lionel ILA, Eswary T, Halijah I, Khalijah A (2008) The cytotoxic and apoptotic effects of 1′S-1′-acetoxychavicol acetate from Alpinia conchigera Griff., on various human tumour cell lines. In: Poster presentation, BioAsia Bangkok 2008-Conference

  • Hasima N, Aun LIL, Azmi MN, Aziz AN, Thirthagiri E, Ibrahim H, Awang K (2010) 1′S-1′-Acetoxyeugenol acetate: a new chemotherapeutic natural compound against MCF-7 human breast cancer cells. Phytomedicine 17(2010):935–939

    Article  CAS  PubMed  Google Scholar 

  • Haslinda MS, Aiyub Z, Bakar NKA, Tohar N, Musa Y, Abdullah NR et al (2015) In vitro antiplasmodial activity, macronutrients and trace metals in the medicinal plants: Phyllanthus spp. and Alpinia conchigera Griff. Trop Biomed 32(1):129–139

    CAS  PubMed  Google Scholar 

  • Hieda Y (2017) Total syntheses of multi-substituted carbazole alkaloids and phenolic related compounds, and evaluation of their antioxidant activities. Yakugaku Zasshi 137(10):1255–1263

    Article  CAS  PubMed  Google Scholar 

  • Huerta C, Castellsague J, Varas-Lorenzo C, Garcia Rodriguez LA (2002) Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population. Am J Kidney Dis 45:531–539

    Article  CAS  Google Scholar 

  • Ibrahim H, Aziz AN, Syamsir DR, Ali NAM, Mohtar M, Ali RM, Awang K (2009) Essential oils of Alpinia conchigera Griff. and their antimicrobial activities. Food Chem 113(2009):575–577

    Article  CAS  Google Scholar 

  • Ibrahim M, Baura J, Ahasan Q, Islam MT, Homa Z, Chowdhury MMU et al (2012) Preliminary phytochemical and pharmacological investigations of Alpinia conchigera Griff. and Plumbago indica L. Bangladesh Pharm J 15(2):153–157

    Article  Google Scholar 

  • Ibrahim M, Hossain MA, Shajib MS, Rashid MA (2018) Preliminary phytochemical and pharmacological screenings of Plumbago indica L. and Alpinia conchigera Griff. Dhaka Univ J Pharm Sci 17(1):73–79

    Article  Google Scholar 

  • Ilavarassan R, Mallika M, Venkataraman S (2005) Anti-inflammatory and antioxidant activities of Cassia fistula Linn bark extracts. Afr J Tradit Complement Altern Med 2:70–85

    Google Scholar 

  • In LLA, Azmi MN, Ibrahim H, Awang K, Nagoor NH (2011) 10S-10-acetoxyeugenol acetate: a novel phenylpropanoid from Alpinia conchigera enhances the apoptotic effects of paclitaxel in MCF-7 cells through NF-κB inactivation. Anticancer Drugs 22:424–434

    Article  CAS  PubMed  Google Scholar 

  • Islam MT, Mata AMOF, Aguiar RPS, Paz MFCJ, Alencar MVOB, Melo-Cavalcante AAC (2016) Therapeutic potential of essential oils focusing on diterpens. Phytother Res 30:1420–1444

    Article  PubMed  Google Scholar 

  • Islam MT, Ali ES, Uddin SJ, Islam MA, Shaw S, Khan IN et al (2018) Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Cancer Lett 420:129–145

    Article  CAS  PubMed  Google Scholar 

  • Janssen AM, Scheffer JJ (1985) Acetoxychavicol acetate, an antifungal component of Alpinia galanga. Planta Med 51(6):507–511

    Article  CAS  PubMed  Google Scholar 

  • Kerley CP (2018) A review of plant-based diets to prevent and treat heart failure. Heart Fail Rev 4(1):54–61

    Google Scholar 

  • Khan T, Gurav P (2018) PhytoNanotechnology: enhancing delivery of plant based anti-cancer drugs. Front Pharmacol 8:1002. https://doi.org/10.3389/fphar.2017.01002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kozłowska A, Szostak-Wegierek D (2014) Flavonoids–food sources and health benefits. Rocz Panstw Zakl Hig 65(2):79–85

    PubMed  Google Scholar 

  • Lee J-H, Jung HS, Giang PM, Jin X, Lee S, Son PT et al (2006) Blockade of nuclear factor-kB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. J Pharmacol Exp Ther 316(1):271–278

    Article  CAS  PubMed  Google Scholar 

  • Li J, Aizawa Y, Hiramoto K, Kasahara E, Tsuruta D, Suzuki T et al (2015) Anti-inflammatory effect of water-soluble complex of 1′-acetoxychavicol acetate with highly branched β-1,3-glucan on contact dermatitis. Biomed Pharmacother 69:201–207

    Article  CAS  PubMed  Google Scholar 

  • Liao NC, Shih YL, Chou JS, Chen KW, Chen YL, Lee MH, Peng SF, Leu SJ, Chung JG (2019) Cardamonin induces cell cycle arrest, apoptosis and alters apoptosis associated gene expression in WEHI-3 mouse leukemia cells. Am J Chin Med 47(3):635–656

    Article  CAS  PubMed  Google Scholar 

  • Liew SK, Azmi MN, In L, Awang K, Nagoor NH (2017) Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1′S-1′-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells. Drug Des Dev Ther 11:2763–2776

    Article  CAS  Google Scholar 

  • Lushchak VI (2015) Free radicals, reactive oxygen species, oxidative stresses and their classifications. Ukr Biochem J 87(6):11–18

    Article  CAS  PubMed  Google Scholar 

  • McGeer PL, McGeer EG (2002) Local neuro inflammation and the progression of Alzheimer’s disease. J Neurovirol 8:529–538

    Article  CAS  PubMed  Google Scholar 

  • Muangmoon R, Junkum A, Chaithong U, Jitpakdi A, Riyong D, Wannasan A et al (2018) Natural larvicides of botanical origin against dengue vector Aedes aegypti (Diptera: culicidae). Southeast Asian J Trop Med Public Health 49(2):227–239

    Google Scholar 

  • Mueller MM (2006) Inflammation in epithelial skin tumors: old stories and new ideas. Eur J Cancer 42:735–744

    Article  CAS  PubMed  Google Scholar 

  • Murugesan D, Deviponnuswamy R (2014) Potential anti-inflammatory medicinal plants—a review. Int J Pharm Pharm Sci 6:43–49

    Google Scholar 

  • Ntie-Kang F, Nwodo JN, Ibezim A, Simoben CV, Karaman B, Ngwa VF et al (2014) Molecular modeling of potential anticancer agents from African medicinal plants. J Chem Inf Model 54(9):2433–2450

    Article  CAS  PubMed  Google Scholar 

  • Ohnishi R, Matsui-Yuasa I, Deguchi Y, Yaku K, Tabuchi M, Munakata H et al (2012) 1′-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am J Chin Med 40(6):1189–1204

    Article  CAS  PubMed  Google Scholar 

  • Olufunmilayo O, Adeyemi SO, Okpo OO (2004) The analgesic effect of the methanolic extract of Acanthus montanus. J Ethnopharmacol 90:45–48

    Article  Google Scholar 

  • Patra JK, Mohanta YK (2014) Antimicrobial compounds from mangrove plants: a pharmaceutical prospective. Chin J Integr Med 20(4):311–320

    Article  CAS  PubMed  Google Scholar 

  • Pengkumsri N, Kantamul C, Towattanakit P, Wongsarat W, Jaiman W, Muangchan N, Chanluang S (2011) Antioxidative effect of Alpinia Conchigera rhizome extracts. Thai Pharm Health Sci J 6(3):195–201

    Google Scholar 

  • Phuah NH, Azmi MN, Awang K, Nagoor NH (2017) Suppression of microRNA-629 enhances sensitivity of cervical cancer cells to 1′S-1′-acetoxychavicol acetate via regulating RSU1. OncoTargets Ther 10:1695–1705

    Article  CAS  Google Scholar 

  • Portenoy RK, Brennan MJ (1994) Chronic pain management. In: Good DC, Couch JR (eds) Handbook of neurorehabilitation. Informa Healthcare, London. ISBN 0-8247-8822-2

    Google Scholar 

  • Rajendran V, Lakshmi KS (2008) In vitro and in vivo anti-inflammatory activity of barks of Symplocos cochinchnesis (lour) Moore ssp laurina. J Pharmacol 3:121–124

    Google Scholar 

  • Rajurkar R, Jain R, Matake N, Aswar P, Khadbadi SS (2009) Antiinflammatory action of Abutilon indicum (L) sweet barks by HRBC membrane stabilization. Res J Pharm Technol 2:415–416

    CAS  Google Scholar 

  • Rana MM, Thammi TJ, Akhter S, Islam MAU (2017) In-vitro evaluation of antioxidant, membrane stabilizing and anthelmintic activities with phytochemical screening of methanolic extract of Alpinia conchigera Griff. Int J Res Pharm Biosci 4(4):16–23

    Google Scholar 

  • Saha D, Paul S (2014) Antibacterial activity of methanol extract of Alpinia conchigera Griff (Family: Zingiberaceae). Albanian J Pharm Sci 2(1):1–3

    Google Scholar 

  • Seo JW, Cho SC, Park SJ, Lee EJ, Lee JH, Han SS et al (2013) 1′-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS ONE 8(2):e56447. https://doi.org/10.1371/journal.pone.0056447

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shih SC, Chang CW (2007) Nonsteroidal anti-inflammatory drug related gastrointestinal bleeding in the elderly. Int J Gerontol 1:40–45

    Article  Google Scholar 

  • Singh V, Krishan P, Shri R (2018) Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice. J Basic Clin Physiol Pharmacol 29(4):403–410

    Article  CAS  PubMed  Google Scholar 

  • Sirat HM, Nordin AB (1995) Chemical composition of the rhizome oil of Alpinia conchigera Griff. from Malaysia. J Essent Oil Res 7(2):195–197

    Article  CAS  Google Scholar 

  • Slattery SA, Niaz O, Aziz Q, Ford AC, Farmer AD (2015) Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther 42(1):3–11

    Article  CAS  PubMed  Google Scholar 

  • Sok SPM, Arshad NM, Azmi MN, Awang K, Ozpolat B, Nagoor NH (2017) The apoptotic effect of 1′S-1′-Acetoxychavicol Acetate (ACA) enhanced by inhibition of noncanonical autophagy in human non-small cell lung cancer cells. PLoS ONE 12(2):e0171329. https://doi.org/10.1371/journal.pone.0171329

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Subramaniam M (2017) Evaluation of Mycobacterium indicus pranii as an immuno-potentiator in combination with 1′S-1′- acetoxychavicol acetate from the malaysian Alpinia conchigera and cisplatin against various cancer types. A thesis paper submitted for the PhD degree under the Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur

  • Sulaiman MR, Zakaria ZA, Adilius M, Mohamad AS, Ismail M, Israf DA (2009) Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera Griff. leaves in various animal models. Methods Find Exp Clin Pharmacol 31(4):241–247

    Article  CAS  PubMed  Google Scholar 

  • Sulaiman MR, Zakaria ZA, Mohamad AS, Ismail M, Hidayat MT, Israf DA, Adilius M (2010) Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera rhizomes in various animal models. Pharm Biol 48(8):861–868

    Article  CAS  PubMed  Google Scholar 

  • Suthisut D, Fields PG, Chandrapatya A (2010) Biological activity of essential oils of Alpinia conchigera rhizome against Sitophilus zeamais and Tribolium castaneum. In: 10th International working conference on stored product protection. Julius-Kühn-Archiv vol. 425, pp. 751–752

  • Suthisut D, Fields PG, Chandrapatya A (2011) Contact toxicity, feeding reduction, and repellency of essential oils from three plants from the ginger family (Zingiberaceae) and their major components against Sitophilus zeamais and Tribolium castaneum. J Econ Entomol 104(4):1445–1454

    Article  CAS  PubMed  Google Scholar 

  • Swati P, Dibyajyot S (2012a) Analgesic activity of methanol extract of Alpinia conchigera Griff. by acetic acid induced writhing method. Asian J Res Pharm Sci 2(2):62–65

    Google Scholar 

  • Swati P, Dibyajyot S (2012b) Evaluation of antimotility effect of Alpinia conchigera Griff. on charcoal induced gastrointestinal motility in mice. Asian J Pharm Res Sci 2(2):71–74

    Google Scholar 

  • Tram LH, Giang PM, Son PT (2007) Further study on chemical constituents and biological activities of Alpinia conchigera Griff. (Zingiberaceae). J Chem 45(2):260–264

    Google Scholar 

  • Ujang ZB, Subramaniam T, Diah MM, Wahid HB, Abdullah BB, Rashid AHBA, Appleton D (2013) Bioguided fractionation and purification of natural bioactives obtained from Alpinia conchigera water extract with melanin inhibition activity. J Biomater Nanobiotechnol 4:265–272

    Article  CAS  Google Scholar 

  • Viswanathan VK, Hodges K, Hecht G (2009) Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea. Nat Rev Microbiol 7(2):110–119

    Article  CAS  PubMed  Google Scholar 

  • Wah TS (2011) Isolation of Kaempferia angustifolia Rosc., Alpinia conchigera Griff. and Curcuma mangga Val., and vanzijp. Phytochemicals and their bioactivities. Thesis submitted to the School of Graduate Studies, University Putra Malaysia

  • Weerakkody NS, Smith WM, Mikkelsen D, Waanders J, Kerven G, Caffin N et al (2012) Purified 1′acetoxychavicol acetate (1′ACA) from galangal spice affects membrane fatty acid composition and triggers a cell envelope stress response in Staphylococcus aureus. Int J Antimicrob Agents 39(3):269–271

    Article  CAS  PubMed  Google Scholar 

  • Wong KC, Lee BC, Lam NF, Ibrahim P (2005) Essential oils of the rhizomes of Alpinia conchigera Griff. and Alpinia latilabris Ridl. Flavour Fragr J 20:431–433

    Article  CAS  Google Scholar 

  • Woodward M, Lowe GD, Campbell DJ, Colman S, Rumley A, Chalmers J et al (2005) Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke 36:2143–2147

    Article  PubMed  Google Scholar 

  • Xie X-Y, Xue Y-M, Xu J-J, He C-G, Yang S-C (2013) Analysis of chemical constituents of volatile oil from Alpinia conchigera Griffith and Alpinia platychilus K. Schumann. J Yunnan Agric Univ (Nat Sci). http://en.cnki.com.cn/Article_en/CJFDTotal-YNDX201304028.htm. Accessed 30 Aug 2019

  • Xu J-J, Zeng G-Z, Yang S-C, Shen Y, Tan N-H (2013) 8-9′ linked neolignans with cytotoxicity from Alpinia conchigera. Fitoterapia 91(2013):82–86

    Article  CAS  PubMed  Google Scholar 

  • Yasuhara T, Manse Y, Morimoto T, Qilong W, Matsuda H, Yoshikawa M, Muraoka O (2009) Acetoxybenzhydrols as highly active and stable analogues of 1′S-1′-acetoxychavicol, a potent antiallergic principal from Alpinia galanga. Bioorg Med Chem Lett 19(11):2944–2946

    Article  CAS  PubMed  Google Scholar 

  • Yu J, Zhou P, Asenso J, Yang XD, Wang C, Wei W (2016) Advances in plant-based inhibitors of P-glycoprotein. J Enzyme Inhib Med Chem 31(6):867–881

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

I am owed to the Department for Management of Science and Technology Development & Faculty of Pharmacy, Ton Duc Thang University, Viet Nam for the overall supporting this research.

Author information

Authors and Affiliations

  1. Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam

    Muhammad Torequl Islam

  2. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam

    Muhammad Torequl Islam

Authors
  1. Muhammad Torequl Islam
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Muhammad Torequl Islam.

Ethics declarations

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

Muhammad Torequl Islam has no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Islam, M.T. A literature-based phyto-pharmacological review on A. conchigera Griff. Orient Pharm Exp Med 19, 379–392 (2019). https://doi.org/10.1007/s13596-019-00397-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13596-019-00397-7

Keywords

Search

Navigation