An up-to-date review on chemistry and biological activities of Senna occidentalis (L.) Link Family: Leguminosae

Abstract

Senna occidentalis (L.) Link Family: Leguminosae, one of the important Ayurvedic plants, to treat various ailments. The current review embarks on the detected secondary metabolites, biological properties and toxicological aspects of extracts of S. occidentalis (L.) Link. With an aim to encourage the recent and advanced research on extracts, the present review is presented. The traditional medicinal importance of S. occidentalis (L.) Link has been identified in tropical and subtropical regions to treat various ailments. All the available informations on S. occidentalis (L.) Link was collected via electronic search (using Pubmed, SciFinder, Scirus, Google Scholar, Agricola and Web of Science) and literature study done at library. About 38 phytocompounds have been isolated from S. occidentalis (L.) Link; the most important includes anthraquinones, flavonoid glycosides, xanthones, tetrahydro anthracenes, terpenes and phytosterol etc. In vivo biological studies of the extracts show that S. occidentalis (L.) Link possesses analgesic, anthelmintic, antidiabetic, anticonvulsant, antitrypanosomal, antioxidant, hepatoprotective, myeloprotective, wound healing, anticancer, anti-inflammatory and larvicidal activity. The extracts need to be further investigated to describe the extent of the biological effects, most advantageous dosage required, and mechanisms of action behind biological effects, safety profile and probable side effects. Moreover, clinical studies are required to support the curative potential of S. occidentalis (L.) Link.

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Abbreviations

EE:

Ethanol extract

BE:

Benzene extract

HE:

Hexane extract

EAE:

Ethyl acetate extract

ME:

Methanol extract

AE:

Aqueous extract

mg/kg:

Milligram/kilogram

h:

Hour

b.w.:

Body weight

mg/ml:

Milligram/milliliter

i.p.:

Intraperitonial

COX:

Cyclooxygenase

MIC:

Minimum: inhibitory concentration

DPPH:

2,2-Diphenyl-1-picrylhydrazyl

NO:

Nitric oxide

H2O2 :

Hydrogen peroxide

TBARS:

Thiobarbituric acid reactive substances

μg/ml:

Microgram/milliliter

NC:

Normocholesterolemic

ppm:

Parts per million

HME:

Hepatomyoencephelopathy

g/kg:

Gram/kilogram

OECD:

Organisation for economic co-operation and development

AEE:

Aqueous ethanolic extract

MCE:

Methanolic chloroform extract

HAE:

Hydro-alcoholic extract

PEE:

Petroleum ether extract

BE:

Benzene extract

CE:

Chloroform extract

n-Bu:

n-Butanol extract

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Correspondence to Harpreet Singh.

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Harpreet Singh has no conflict of interest. Piyush Chahal has no conflict of interest. Amrita Mishra has no conflict of interest. Arun Kumar Mishra has no conflict of interest.

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Singh, H., Chahal, P., Mishra, A. et al. An up-to-date review on chemistry and biological activities of Senna occidentalis (L.) Link Family: Leguminosae. ADV TRADIT MED (ADTM) 20, 263–278 (2020). https://doi.org/10.1007/s13596-019-00391-z

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Keywords

  • Secondary metabolites
  • Senna occidentalis (L.) Link
  • Phytocompounds