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Gastroprotective and digestive potential of an Ayurvedic asava–arishta preparation

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Abstract

Asavas and arishtas are considered as important Ayurvedic self-fermented dosage forms which are being used widely to promote health and well-being and for management of digestive and metabolic disorders. The present investigation was carried out to study the potential of an Ayurvedic polyherbal asava–arishta preparation (ZP) in gastroprotection, intestinal motility and gastric dyspepsia in experimental rodent models. The gastroprotective effect of ZP at doses 1.5, 3 and 6 ml/kg of body weight was studied using battery of animal models such as pyloric ligation in rats, intestinal transit time using charcoal meal test, gastric emptying and digestive stimulation action in rats. In addition, anti-spasmodic activity was studied using isolated guinea pig’s ileum. The role digestive enzymes such as pepsin, α-amylase and lipase were accessed by various enzymatic assays. A dose-dependent and statistically significant (p < 0.01) inhibitory effect on reducing gastric volume, free acidity, total acidity and ulcer index were observed in ZP treated animals as compared to the control. ZP also enhanced the mucin content of the gastric juice. Pre-treatment with ZP produced a dose-dependent effect in reducing intestinal motility, intestinal spasms and increased the gastric emptying time in rats. These observations validated the age old claims of ZP for its use as digestive tonic. Thus, results concluded that ZP is having potential to improve digestion and reduces recurrent digestive ailments.

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Acknowledgements

The Ayurvedic asava–arishta formulation is being manufactured and marketed by Emami Limited under the brand name of Zandu Pancharishta. The authors express their gratitude to Emami Limited, Kolkata for the financial support to carry out this study. The authors are also thankful to the Department of Pharmacology, R. G. Kar Medical College and Hospital, Kolkata for providing the experimental facilities.

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Authors and Affiliations

  1. Department of Pharmacology, R. G. Kar Medical College and Hospital, Khudiram Bose Sarani, Kolkata, West Bengal, 700004, India

    Anjan Adhikari

  2. Research and Development Centre, Healthcare Division, Emami Limited, 13, BT Road, Belgharia, Kolkata, West Bengal, 700056, India

    Amitabha Dey, Satyajyoti Kanjilal, Rajarshi Biswas, Deepa Gandhi, Kamarujjaman Mondal, Bibhuti Nath Bhatt, Satyabrata Mohapatra, Avinash Narwaria & Chandra Kant Katiyar

  3. Department of Pharmacology, Institute of Post Graduate Medical Education and Research and SSKM Hospital, 244B AJC Bose Road, Kolkata, 700020, India

    Tapas Kumar Sur

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  1. Anjan Adhikari
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  2. Amitabha Dey
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  3. Satyajyoti Kanjilal
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  4. Rajarshi Biswas
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  6. Kamarujjaman Mondal
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  7. Bibhuti Nath Bhatt
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  8. Tapas Kumar Sur
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  9. Satyabrata Mohapatra
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  10. Avinash Narwaria
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  11. Chandra Kant Katiyar
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Correspondence to Satyajyoti Kanjilal.

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Ethical statement

Ethical clearance for animal experimental work was obtained from the Institutional Animal Ethical Committee of the R.G. Kar medical College and Hospital, Kolkata prior to the commencement of experiments (Registration number: R/N 959/C/06/CPCSEA).

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This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors.

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Adhikari, A., Dey, A., Kanjilal, S. et al. Gastroprotective and digestive potential of an Ayurvedic asava–arishta preparation. Orient Pharm Exp Med 18, 391–401 (2018). https://doi.org/10.1007/s13596-018-0325-y

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  • DOI: https://doi.org/10.1007/s13596-018-0325-y

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