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Horticulture, Environment, and Biotechnology

, Volume 59, Issue 1, pp 131–137 | Cite as

Determination of flavonoids in Acer okamotoanum and their aldose reductase inhibitory activities

  • Jaemin Lee
  • Dong-Gu Lee
  • Joyce P. Rodriguez
  • Jun Yeon Park
  • Eun Ju Cho
  • Sonia D. Jacinto
  • Sanghyun Lee
Research Report

Abstract

Plants in the genus Acer include medicinal plants and deciduous tree species in which several bioactive compounds have been isolated. In this study, flavonoids were isolated from the aerial parts of Acer okamotoanum by open column chromatography and identified by spectroscopic analysis as afzelin, quercitrin, and isoquercitrin. Among these flavonoids, quercitrin and isoquercitrin exhibited potent aldose reductase inhibitory activity (IC50 value of 0.40 and 0.63 μM, respectively). Almost all studied tissues of Acer spp. contained high amounts of quercitrin. The leaf of A. mono had the highest amount of quercitrin (61.90 μg g−1). Our results demonstrated that Acer species contain high concentrations of flavonoids with promising aldose reductase inhibitory activity that could be utilized to develop novel therapeutics for diabetic disorders.

Keywords

Aceraceae Bioassay Constituent Flavonoid 

Notes

Acknowledgements

This work was supported by the Chung-Ang University Research Grants in 2017 and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01058868).

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Copyright information

© Korean Society for Horticultural Science and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jaemin Lee
    • 1
  • Dong-Gu Lee
    • 1
  • Joyce P. Rodriguez
    • 1
  • Jun Yeon Park
    • 2
  • Eun Ju Cho
    • 3
  • Sonia D. Jacinto
    • 4
  • Sanghyun Lee
    • 1
  1. 1.Department of Integrative Plant ScienceChung-Ang UniversityAnseongRepublic of Korea
  2. 2.College of Korean MedicineGachon UniversitySeongnamRepublic of Korea
  3. 3.Department of Food Science and NutritionPusan National UniversityBusanRepublic of Korea
  4. 4.Institute of BiologyUniversity of the Philippines, DilimanQuezonPhilippines

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