Human Cell

, Volume 32, Issue 3, pp 231–239 | Cite as

Function of innate lymphoid cells in the immune-related disorders

  • Tanja Dzopalić
  • Biljana Božić-Nedeljković
  • Vladimir JurišićEmail author
Review Article


Innate lymphoid cells (ILCs) are a recently described group of innate immune cells that mirror the characteristics of CD4+ T cell subsets. Based on their transcriptional factor and cytokine profile, ILCs family is divided into main subgroups—ILC1s, ILC2s, and ILC3s. Recently, one new subpopulation of ILCs with immunosuppressive characteristics has been described and named as regulatory ILCs. Various roles of ILCs have been confirmed including the role during the response to microbial signals, the role in inflammation and process of tissue repair. Function of ILCs is mediated through the cytokines production and direct cell-to-cell contact. This article summarizes in detail, the relationship between the ILCs and various immune-related disorders.


Innate lymphoid cells Cytokines Inflammation Tissue repair 



The authors thank the support of the Ministry of Education, Science and Technological Development of the Republic of Serbia (projects numbers 175102, 175056).

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interest.


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© Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Biomedical Research, Faculty of MedicineUniversity of NišNisSerbia
  2. 2.Faculty of BiologyUniversity of BelgradeBelgradeSerbia
  3. 3.Faculty of Medical SciencesUniversity of KragujevacKragujevacSerbia

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