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Human Cell

, Volume 31, Issue 3, pp 268–270 | Cite as

Expression of miR-132 in Down syndrome subjects

  • Michele Salemi
  • Concetta Barone
  • Maria Grazia Salluzzo
  • Mariaconcetta Giambirtone
  • Federico Ridolfo
  • Corrado Romano
Letter to the Editor
  • 56 Downloads

Dear Sir,

Down syndrome (DS) is caused by the presence of three human chromosome 21 copies, this trisomy is the most frequent genetic etiology associated with a number of deleterious phenotypes in humans, where is included intellectual disability [1].

Gene expression plays a central role in neuronal plasticity and in dysfunction of the molecular events that can lead to severe neuronal disorders.

In addition, to coding transcripts (mRNAs), non-coding microRNAs (miRNAs) appear to play a role in these processes [2]. MiRNAs are short non-coding RNAs (∼ 22 nucleotide) that mediate post-transcriptional gene silencing [3]. MiRNAs play a role in early neuronal development and in neurodegenerative diseases [4].

Previous studies on DS mainly focused on human chromosome 21-derived miRNAs, and few studies focused in total miRNAs expression profile from human blood samples [5].

Many miRNAs were detected to have significantly different expression, which may be involved in DS variable phenotypes [6].

Keywords

MiR-132 Intellectual disability Down syndrome mRNA expression 

Notes

Compliance with ethical standards

Conflict of interest

The authors report no declarations of interest.

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Copyright information

© Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Oasi Research Institute-IRCCSTroinaItaly
  2. 2.Department of Transfusional MedicineGeneral Hospital of TrevisoTrevisoItaly

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