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Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis

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Abstract

To investigate the clinical significance of human wings apart-like (hWAPL) genetic polymorphisms in cervical carcinogenesis. hWAPL polymorphisms and human papillomavirus (HPV) types were examined in 175 cervical smears of exfoliated cervical cell samples using a real-time polymerase chain reaction system. A significant difference was detected in the frequency of the CC genotype between the HPV(+) low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) groups [Odds ratio 0.21, 95% confidence interval (CI) 0.0723–0.61; P = 0.0029]. A significant difference was noted in the frequency of the CC genotype between the high-risk HPV-positive LSIL and HSIL groups (odds ratio 0.2955, 95% CI 0.0893–0.9771; P = 0.0414). The CC genotype of hWAPL gene promoter polymorphism may be associated with cervical carcinogenesis.

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Authors and Affiliations

  1. Department of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan

    Osamu Nunobiki, Daisuke Sano & Sakae Hata

  2. Department of Obstetrics and Gynecology, Okubo Hospital, Akashi, Hyogo, Japan

    Toshitada Ogasawara

  3. Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan

    Masatsugu Ueda

Authors
  1. Osamu Nunobiki
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  2. Daisuke Sano
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  3. Sakae Hata
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  4. Toshitada Ogasawara
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  5. Masatsugu Ueda
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Correspondence to Osamu Nunobiki.

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Nunobiki, O., Sano, D., Hata, S. et al. Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis. Human Cell 31, 149–153 (2018). https://doi.org/10.1007/s13577-018-0200-7

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  • DOI: https://doi.org/10.1007/s13577-018-0200-7

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