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The relationship between GRACE risk score and glucose fluctuation in patients with acute coronary syndrome and abnormal glucose metabolism

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Abstract

The aim of this study was to determine the relationship between glucose fluctuation and global registry of acute coronary events (GRACE) risk score in patients with acute coronary syndrome (ACS) and abnormal glucose metabolism using continuous glucose monitoring system (CGMS). A total of 76 patients with ACS admitted into coronary care unit (CCU) were divided into two groups based on their blood glucose level and were further divided into subgroups based on GRACE risk score. A CGMS was used to real-time monitor blood glucose for 72 h in all patients after admitted into CCU. Twenty-four-hour mean blood glucose (24-h MBG) and 24-h mean amplitude of glycemic excursion (24-h MAGE) were calculated. Among the 76 patients, 52 patients had abnormal glucose metabolism. Among the 52 patients, there were 8 patients in low-risk group, 19 patients in moderate-risk group, and 25 in high-risk group. Among the 24 patients with normal glucose metabolism, there were 6 patients in the low-risk group, 6 patients in the moderate-risk group, and 12 in the high-risk group based on GRACE score. For patients with abnormal glucose metabolism, the 24-h MBG and 24-h MAGE of moderate- and high-risk groups were significantly higher than that of the low-risk group, which were not found in patients with ACS and normal glucose metabolism. High prevalence of abnormal glucose metabolism was found in ACS patients admitted into CCU and larger blood glucose fluctuation is associated with moderate and high GRACE risk scores in patients with ACS and abnormal glucose metabolism.

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Acknowledgements

The study was supported by the fund of Scientific and Technological Development Program of Jiangsu Province of China (BL2014010).

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Author notes

  1. Huiqin Li and Chunfeng Lu equally contributed as first authors.

Authors and Affiliations

  1. Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China

    Huiqin Li, Chunfeng Lu, Liying Xu, Jianhua Ma & Xiaofei Su

  2. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China

    Nailiang Tian, Xiaofei Gao, Zhongguo Fan & Shaoliang Chen

  3. National Heart Centre Singapore, National Heart Research Institute Singapore, Singapore, Singapore

    Lei Ye

  4. Department of Endocrinology, Nanjing Medical University Affiliated Nanjing Hospital, Nanjing, 210006, China

    Jianhua Ma & Xiaofei Su

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  1. Huiqin Li
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Correspondence to Jianhua Ma.

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Li, H., Lu, C., Xu, L. et al. The relationship between GRACE risk score and glucose fluctuation in patients with acute coronary syndrome and abnormal glucose metabolism. Int J Diabetes Dev Ctries 38, 195–201 (2018). https://doi.org/10.1007/s13410-017-0576-z

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  • DOI: https://doi.org/10.1007/s13410-017-0576-z

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