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Fe3O4–ZnO Core–Shell Nanoparticles Fabricated by Ultra-Thin Atomic Layer Deposition Technique as a Drug Delivery Vehicle

  • Original Article - Nanomaterials
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Abstract

Fe3O4–ZnO nanoparticles with core–shell structures were successfully fabricated by an atomic layer deposition method. The core–shell NPs consisted of superparamagnetic Fe3O4 cores of 100 nm average size and conformal ZnO shells of 10 nm thickness. The NPs showed a saturation magnetization of ~ 23 emu/g, which is suitable for magnetic delivery of the particles. Cytotoxicity testing revealed that the Fe3O4–ZnO NPs have high cell viability (over 90%) after 24 h culture. Also, they exhibited a high ibuprofen-loading capacity (640 μg per mg of the particles) and good release ability (> 90% after 72 h in simulated body fluid). As a result, the Fe3O4–ZnO nanoparticles with conformal ultra-thin ZnO shell layers are anticipated as promising drug delivery vehicles with acceptable cell viability and high drug loading-release abilities.

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Acknowledgements

This work was supported by the Basic Science Research Program (2012R1A6A1029029) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education and the Ministry of Science, ICT and Future Planning.

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Author notes

  1. Sejong Seong and In-Sung Park have contributed equally to this work.

Authors and Affiliations

  1. Division of Materials Science and Engineering, Hanyang University, Seoul, 04763, Korea

    Sejong Seong, In-Sung Park, Yong Chan Jung, Taehoon Lee, Seon Yong Kim & Jinho Ahn

  2. Institute of Nano Science and Technology, Hanyang University, Seoul, 04763, Korea

    In-Sung Park & Jinho Ahn

  3. Department of Life Science, Hanyang University, Seoul, 04763, Korea

    Su-Jae Lee

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  1. Sejong Seong
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Seong, S., Park, IS., Jung, Y.C. et al. Fe3O4–ZnO Core–Shell Nanoparticles Fabricated by Ultra-Thin Atomic Layer Deposition Technique as a Drug Delivery Vehicle. Electron. Mater. Lett. 15, 493–499 (2019). https://doi.org/10.1007/s13391-019-00147-6

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