Expression of TSLC1 in patients with HAM/TSP

Abstract

Human T-lymphotropic virus type 1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has been reported in peripheral blood. This study aims to explore the expression level of the adhesion molecule during the expression level of the adhesion molecule among HAM/TSP disease activity. In lymphocyte function–associated antigen 1 and DNAX accessory molecule 1, no variation in expression levels specific to HTLV-1 infection was observed in CD4-positive T cells; however, TSLC1 expression was higher in HAM patients than in asymptomatic carriers and non-infected persons. TSLC1 tended to be higher in patients whose symptoms were worsening. On the contrary, the expression level of TSLC1 in CD8-positive T cells was lower in HAM patients than in asymptomatic carriers, and this tendency was stronger in patients whose symptoms had deteriorated. No significant correlation was found between TSLC1 and either of the transcription factors Tax or HBZ in any T cell group. Therefore, TSLC1 expression in CD4-positive T cells might be a useful biomarker of HAM/TSP disease activity.

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Acknowledgments

We thank Enago (www.enago.jp) for the English language review.

Funding

This work was supported partly by KAKENHI Grant Number 245911280 from JSPS, and the Japan Agency for Medical Research and Development (AMED) (NT: 16ek0109026h0003, MT: 17fk0108111j0101). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

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Correspondence to Masakazu Tanaka.

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Takenouchi, N., Tanaka, M., Sato, T. et al. Expression of TSLC1 in patients with HAM/TSP. J. Neurovirol. 26, 404–414 (2020). https://doi.org/10.1007/s13365-020-00838-z

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Keywords

  • Human T-lymphotropic virus type I (HTLV-I)
  • HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
  • Tumor suppressor in lung cancer-1 (TSLC1)
  • Clinical symptoms