Release pattern of dexamethasone after administration through an implant-mediated drug delivery device with an active plunger of super absorbent polymer
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The implant-mediated drug delivery system (IMDDS) is a novel, innovative device that allows drug delivery through bone marrow. The purpose of this study was to investigate the effect of an active plunger component made of super absorbent polymer (SAP) on the plasma concentration of dexamethasone released from the IMDDS. The IMDDSs were installed in a total of 18 rabbits. After complete healing, dexamethasone was loaded with the SAP active plunger and with water to cause expansion in the test group (n = 9), while only the drug was loaded in the control group, as per the original protocol (n = 9). The release patterns of each group were monitored for 2 weeks by measuring the plasma concentration of the drug. Both groups showed sustained release of drug. However, the test groups showed more rapid increase in plasma concentration and higher area under the curve (AUC) throughout the observation period. The incorporation of a SAP active plunger component in the IMDDS resulted in an increase in initial release of drug and higher bioavailability within the observation period of 2 weeks after dexamethasone administration.
KeywordsOsseogate Implant-mediated drug delivery system Super absorbent polymer Active plunger Dexamethasone
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Healthand Welfare, Republic of Korea (Grant no. H I13C1474).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Park YS, Lee SJ, Hwang CI. New application of endosseous implants—implant mediated drug delivery system (IMDDS). J Korean Dent Assoc. 2014;52:550–7.Google Scholar
- 4.Park JH, Cha HS, Kim HK, Park YS. Dexamethasone delivery by an implant-mediated drug delivery system in the canine mandible. J Periodontol. 2016:1–9.Google Scholar
- 18.Borot S, Franc S, Cristante J, Penfornis A, Benhamou PY, Guerci B, et al. Accuracy of a new patch pump based on a microelectromechanical system (MEMS) compared to other commercially available insulin pumps: results of the first in vitro and in vivo studies. J Diabet Sci Technol. 2014;8:1133–41.CrossRefGoogle Scholar
- 21.Xie X, Yang Y, Yang Y, Li Z, Zhang H, Chi Q, et al. The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive. Drug Deliv. 2015:1–12.Google Scholar
- 24.Gandhi BR, Mundada AS, Gandhi PP. Chronopharmaceutics: as a clinically relevant drug delivery system. Drug Deliv. 2011;18, 18(1)Google Scholar