Polymer-wrapped single-walled carbon nanotubes: a transformation toward better applications in healthcare

  • Mazzura Wan Chik
  • Zahid Hussain
  • Mohd Zulkefeli
  • Minaketan Tripathy
  • Sunil Kumar
  • Abu Bakar Abdul Majeed
  • K. Byrappa
Review Article


Carbon nanotubes (CNTs) possess outstanding properties that could be useful in several technological, drug delivery, and diagnostic applications. However, their unique physical and chemical properties are hindered due to their poor solubility. This article review’s the different ways and means of solubility enhancement of single-wall carbon nanotubes (SWNTs). The advantages of SWNTs over the multi-walled carbon nanotubes (MWNTs) and the method of non-covalent modification for solubility enhancement has been the key interest in this review. The review also highlights a few examples of dispersant design. The review includes some interesting utility of SWNTs being wrapped with polymer especially in biological media that could mediate proper drug delivery to target cells. Further, the use of wrapped SWNTs with phospholipids, nucleic acid, and amphiphillic polymers as biosensors is of research interest. The review aims at summarizing the developments relating to wrapped SWNTs to generate further research prospects in healthcare.


Carbon nanotubes Single-wall carbon nanotubes Superhydrophobicity Polymer wrapping Solubility enhancers Targeted drug delivery 



The authors would like to acknowledge the Ministry of Higher Education (MOHE) Malaysia for Fundamental Research Grant Scheme (600-RMIA/FRGS 5/3 (4/2014)) and Universiti Teknologi MARA for providing support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Controlled Release Society 2018

Authors and Affiliations

  • Mazzura Wan Chik
    • 1
  • Zahid Hussain
    • 1
  • Mohd Zulkefeli
    • 2
  • Minaketan Tripathy
    • 1
    • 3
  • Sunil Kumar
    • 4
  • Abu Bakar Abdul Majeed
    • 3
  • K. Byrappa
    • 5
  1. 1.Laboratory Fundamental of Pharmaceutics, Faculty of PharmacyUniversity Teknologi MARA (UiTM)Bandar Puncak AlamMalaysia
  2. 2.Department of Pharmaceutical chemistry, School of PharmacyInternational Medical UniversityKuala LumpurMalaysia
  3. 3.Pharmaceutical Life Sciences Department, Faculty of PharmacyUniversity Teknologi MARA (UiTM)Bandar Puncak AlamMalaysia
  4. 4.ICAR-NBAIMKushmaurIndia
  5. 5.Mangalore UniversityMangaloreIndia

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