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pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity

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Abstract

Diabetic wounds as chronic wounds represent a severe, persistent complication of diabetes and, in the most extreme cases, can lead to amputation. Two critical and unfavorable factors affecting diabetic wound healing are sustained bacterial-induced chronic inflammation and disrupted vascularization. In this paper, we presented a novel, pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharides, and explored its potential for accelerating diabetic wound healing. A thorough investigation indicated that the drug- and nanoparticle-loaded hydrogel demonstrated strong bactericidal behavior mediated by protamine nanoparticles and reduced bacterial-induced chronic inflammation at the wound site. Furthermore, it accelerated the wound-healing process by promoting angiogenesis in skin wounds with the hyaluronan oligosaccharide-mediated enhanced expression of vascular endothelial growth factor.

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Acknowledgements

English-language editing of this manuscript was provided by Journal Prep.

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Author notes

  1. Tao Wang and Yan Zheng contributed equally to this work.

Authors and Affiliations

  1. School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People’s Republic of China

    Tao Wang, Yan Zheng, Yijie Shi & Liang Zhao

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  1. Tao Wang
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  2. Yan Zheng
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  3. Yijie Shi
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  4. Liang Zhao
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Correspondence to Liang Zhao.

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All animal studies were conducted according to the regulations for animal experimentation issued by the State Committee of Science and Technology of the People’s Republic of China.

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Wang, T., Zheng, Y., Shi, Y. et al. pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity. Drug Deliv. and Transl. Res. 9, 227–239 (2019). https://doi.org/10.1007/s13346-018-00609-8

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  • DOI: https://doi.org/10.1007/s13346-018-00609-8

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