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Low resting energy expenditure in postmenopausal Japanese women with type 2 diabetes mellitus

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Abstract

Objective

Resting energy expenditure (REE) is an important tool in nutrition management, especially in type 2 diabetes mellitus (T2DM). The predicted REE (pREE) was reported to be inaccurate, compared with measured REE (mREE) in Japanese T2DM patients. Despite the accuracy of REE, measured via indirect calorimetry (mREE), the technique is demanding. This study evaluated the associated clinical factors of the difference between pREE and mREE in Japanese patients with T2DM.

Methods

Forty-nine Japanese patients with T2DM but no severe complications (32 men and 17 women) were enrolled. mREE was determined via indirect calorimetry.

Results

Participants average age was 56.3 ± 11.0 years, body mass index was 25.2 ± 3.6 kg/m2, and HbA1c was 9.6 ± 1.6%. The mean mREE was 1099 ± 212 kcal/day. Age, body mass index, hemoglobin, and uric acid levels were all associated with mREE by simple regression; of these, body weight was the significant factor in the multiple regression analysis. When the patients were divided into tertiles, the average mREE values were lower than the pREE values for each group. The difference between mREE and pREE was largest in the lowest value group, whose subjects were mostly women aged over 50 years. This group of women showed significantly lower mREE (904 ± 121 kcal) in comparison with men in the same age group, with 26% overestimation of pREE, even when the equation that yielded the closest mREE value was used.

Conclusion

The previously reported pREE overestimates mREE in Japanese patients with T2DM, especially in postmenopausal women.

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Acknowledgements

We thank Ms. M Tomioka for her technical assistance. This study was partially supported by a research Grants from the Shukutoku University.

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Authors and Affiliations

  1. Diabetes Center, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan

    Risa Ide, Makiko Ogata, Naoko Iwasaki & Tetsuya Babazono

  2. Department of Food and Nutrition, Faculty of home Economics, Tokyo Kasei University, 1-18-1 Itabashiku, Tokyo, 1738602, Japan

    Makiko Ogata

  3. School of Nutrition, College of Nursing and Nutrition, Shukutoku University, Chiba, Japan

    Makiko Ogata

  4. Institute of Geriatrics, Tokyo Women’s Medical University, Tokyo, Japan

    Naoko Iwasaki

Authors
  1. Risa Ide
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  2. Makiko Ogata
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Correspondence to Makiko Ogata.

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All authors have no conflicts of interest to declare.

Human and animals rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and/or with the Helsinki Declaration of 1964 and later versions. Informed consent or substitute for it was obtained from all patients for being included in the study.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration, and the study protocol complied with the Ethical Guidelines for Medical and Health Research Involving Human Subjects. The study design was approved by the Ethics Committee of the Tokyo Women’s Medical University School of Medicine (9 May, 2017 No. 3829R).

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Ide, R., Ogata, M., Iwasaki, N. et al. Low resting energy expenditure in postmenopausal Japanese women with type 2 diabetes mellitus. Diabetol Int 10, 268–278 (2019). https://doi.org/10.1007/s13340-019-00391-z

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